Chalcones identify cTXNPx as a potential antileishmanial drug target

With current drug treatments failing due to toxicity, low efficacy and resistance; leishmaniasis is a major global health challenge that desperately needs new validated drug targets. Inspired by activity of the natural chalcone 2’,6’-dihydroxy-4’-methoxychalcone (DMC), the nitro-analogue, 3-nitro-2’...

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Detalles Bibliográficos
Autores principales: Escrivani, Douglas O., Charlton, Rebecca L., Caruso, Marjolly B., Burle-Caldas, Gabriela A., Borsodi, Maria Paula G., Zingali, Russolina B., Arruda-Costa, Natalia, Palmeira-Mello, Marcos V., de Jesus, Jéssica B., Souza, Alessandra M. T., Abrahim-Vieira, Bárbara, Freitag-Pohl, Stefanie, Pohl, Ehmke, Denny, Paul W., Rossi-Bergmann, Bartira, Steel, Patrick G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664226/
https://www.ncbi.nlm.nih.gov/pubmed/34780470
http://dx.doi.org/10.1371/journal.pntd.0009951

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