COVID-19 and BRD4: a stormy and cardiotoxic bromo-romance

Severe systemic inflammation in COVID-19 patients can lead to dysfunction of multiple organs, including the heart. Using an ex vivo cardiac organoid system, Mills et al discovered that inhibitors of the chromatin reader protein, bromodomain-containing protein 4, protect cardiomyocytes from COVID-ass...

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Detalles Bibliográficos
Autores principales: Robinson, Emma L., McKinsey, Timothy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664241/
https://www.ncbi.nlm.nih.gov/pubmed/34901955
http://dx.doi.org/10.20517/jca.2021.20
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author Robinson, Emma L.
McKinsey, Timothy A.
author_facet Robinson, Emma L.
McKinsey, Timothy A.
author_sort Robinson, Emma L.
collection PubMed
description Severe systemic inflammation in COVID-19 patients can lead to dysfunction of multiple organs, including the heart. Using an ex vivo cardiac organoid system, Mills et al discovered that inhibitors of the chromatin reader protein, bromodomain-containing protein 4, protect cardiomyocytes from COVID-associated “cytokine storm”. We briefly review these important findings and highlight the translational significance of the work.
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spelling pubmed-86642412022-01-01 COVID-19 and BRD4: a stormy and cardiotoxic bromo-romance Robinson, Emma L. McKinsey, Timothy A. J Cardiovasc Aging Article Severe systemic inflammation in COVID-19 patients can lead to dysfunction of multiple organs, including the heart. Using an ex vivo cardiac organoid system, Mills et al discovered that inhibitors of the chromatin reader protein, bromodomain-containing protein 4, protect cardiomyocytes from COVID-associated “cytokine storm”. We briefly review these important findings and highlight the translational significance of the work. 2022-01-01 2022 /pmc/articles/PMC8664241/ /pubmed/34901955 http://dx.doi.org/10.20517/jca.2021.20 Text en https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Robinson, Emma L.
McKinsey, Timothy A.
COVID-19 and BRD4: a stormy and cardiotoxic bromo-romance
title COVID-19 and BRD4: a stormy and cardiotoxic bromo-romance
title_full COVID-19 and BRD4: a stormy and cardiotoxic bromo-romance
title_fullStr COVID-19 and BRD4: a stormy and cardiotoxic bromo-romance
title_full_unstemmed COVID-19 and BRD4: a stormy and cardiotoxic bromo-romance
title_short COVID-19 and BRD4: a stormy and cardiotoxic bromo-romance
title_sort covid-19 and brd4: a stormy and cardiotoxic bromo-romance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664241/
https://www.ncbi.nlm.nih.gov/pubmed/34901955
http://dx.doi.org/10.20517/jca.2021.20
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