MLL4 mediates differentiation and tumor suppression through ferroptosis

The epigenetic regulator, MLL4 (KMT2D), has been described as an essential gene in both humans and mice. In addition, it is one of the most commonly mutated genes in all of cancer biology. Here, we identify a critical role for Mll4 in the promotion of epidermal differentiation and ferroptosis, a key...

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Detalles Bibliográficos
Autores principales: Egolf, Shaun, Zou, Jonathan, Anderson, Amy, Simpson, Cory L., Aubert, Yann, Prouty, Stephen, Ge, Kai, Seykora, John T., Capell, Brian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664260/
https://www.ncbi.nlm.nih.gov/pubmed/34890228
http://dx.doi.org/10.1126/sciadv.abj9141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664260/
https://www.ncbi.nlm.nih.gov/pubmed/34890228
http://dx.doi.org/10.1126/sciadv.abj9141

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