Long term persistence of coronavirus SARS-CoV-2 infection

During the COVID-19 pandemic, a case of a long-term persistence of SARS-CoV-2 infection (from March 26 to May 20, 2020) was identified at a private hospital in São Paulo, SP, Brazil. The long-term positivity for SARS-CoV-2 in reverse transcriptase polymerase chain reaction tests of a patient diagnos...

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Detalles Bibliográficos
Autores principales: Pinho, João Renato Rebello, de Oliveira, Ketti Gleyzer, Sitnik, Roberta, Maluf, Maira Marranghello, Rodrigues, Pedro Henrique Sebe, Santana, Rúbia Anita Ferraz, Welter, Eliane Rosseto, Irony, Ophir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Israelita de Ensino e Pesquisa Albert Einstein 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664288/
https://www.ncbi.nlm.nih.gov/pubmed/34909977
http://dx.doi.org/10.31744/einstein_journal/2021RC6369
Descripción
Sumario:During the COVID-19 pandemic, a case of a long-term persistence of SARS-CoV-2 infection (from March 26 to May 20, 2020) was identified at a private hospital in São Paulo, SP, Brazil. The long-term positivity for SARS-CoV-2 in reverse transcriptase polymerase chain reaction tests of a patient diagnosed with COVID-19 suggests, at least part of patients who recovered, may still carry and transmit the SARS-CoV-2 virus. This fact emphasizes the importance of having at least two negative reverse transcriptase polymerase chain reaction test results for SARS-CoV-2. Serological assays were not particularly helpful in the case described, since the patient had very low antibodies titers at the end of the follow-up period. Low viral loads may not be detected by current molecular methods, leading to wrong conclusions regarding viral clearance.

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