Wnt signaling mediates acquisition of blood–brain barrier properties in naïve endothelium derived from human pluripotent stem cells

Endothelial cells (ECs) in the central nervous system (CNS) acquire their specialized blood–brain barrier (BBB) properties in response to extrinsic signals, with Wnt/β-catenin signaling coordinating multiple aspects of this process. Our knowledge of CNS EC development has been advanced largely by an...

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Detalles Bibliográficos
Autores principales: Gastfriend, Benjamin D, Nishihara, Hideaki, Canfield, Scott G, Foreman, Koji L, Engelhardt, Britta, Palecek, Sean P, Shusta, Eric V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664294/
https://www.ncbi.nlm.nih.gov/pubmed/34755601
http://dx.doi.org/10.7554/eLife.70992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664294/
https://www.ncbi.nlm.nih.gov/pubmed/34755601
http://dx.doi.org/10.7554/eLife.70992

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