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Clinical and Microbiological Characteristics of Infective Endocarditis at a Cardiac Center in Saudi Arabia
BACKGROUND: Infective endocarditis (IE) is a serious disease with complex pathology and significant mortality. Little information is known regarding clinical and microbiological characteristics in Saudi Arabia. This study surveyed these characteristics at a Cardiac Center in Riyadh, Saudi Arabia ove...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664328/ https://www.ncbi.nlm.nih.gov/pubmed/34735715 http://dx.doi.org/10.1007/s44197-021-00013-5 |
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author | Barry, Mazin Bari, Syed Abdul Akhtar, Muhammad Yasin Al Nahdi, Faizah Erlandez, Richilda Al Khushail, Abdullah Al Hebaishi, Yahya |
author_facet | Barry, Mazin Bari, Syed Abdul Akhtar, Muhammad Yasin Al Nahdi, Faizah Erlandez, Richilda Al Khushail, Abdullah Al Hebaishi, Yahya |
author_sort | Barry, Mazin |
collection | PubMed |
description | BACKGROUND: Infective endocarditis (IE) is a serious disease with complex pathology and significant mortality. Little information is known regarding clinical and microbiological characteristics in Saudi Arabia. This study surveyed these characteristics at a Cardiac Center in Riyadh, Saudi Arabia over a period of 5 years. METHODS: This retrospective study was done on all infective endocarditis (IE) patients admitted to Prince Sultan Cardiac Center between January 1, 2015, and December 31, 2019. Clinical characteristics, microbiological results, management, and outcomes were assessed. RESULT: A total of 340 cases of infective endocarditis were identified over the study period. Most patients (64%) were 50 years old or above, and 67% were males. Fever was the most common clinical presentation, and a murmur was audible in a fifth of patients. Blood cultures were positive in 177 (52%) cases. The most common organisms were Staphylococcus aureus, coagulase negative Staphylococcus and viridans group Streptococcus. Most common microbiological organisms causing native valve endocarditis were viridans group Streptococcus (32%) followed by methicillin-susceptible Staphylococcus aureus (21%), and for prosthetic valve endocarditis they were coagulase negative Staphylococcus (32%) followed by methicillin-susceptible Staphylococcus aureus (23%), the most common causes of culture negative endocarditis were Q-fever and brucellosis. Predisposing cardiac conditions were present in 127 (37%) patients, most commonly rheumatic heart disease and congenital heart disease. Surgical intervention was done in 26% of cases, with an overall in-hospital mortality rate of 6.76%. CONCLUSION: We demonstrate the epidemiological, clinical, and microbiological profile of infective endocarditis in a tertiary care cardiac center in Saudi Arabia. It gives information concerning the prevalence of responsible organisms. This information will be helpful in assessing patients with suspected IE and in planning management of cases knowing the relative frequency of types of microorganisms encountered. |
format | Online Article Text |
id | pubmed-8664328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-86643282021-12-27 Clinical and Microbiological Characteristics of Infective Endocarditis at a Cardiac Center in Saudi Arabia Barry, Mazin Bari, Syed Abdul Akhtar, Muhammad Yasin Al Nahdi, Faizah Erlandez, Richilda Al Khushail, Abdullah Al Hebaishi, Yahya J Epidemiol Glob Health Research Article BACKGROUND: Infective endocarditis (IE) is a serious disease with complex pathology and significant mortality. Little information is known regarding clinical and microbiological characteristics in Saudi Arabia. This study surveyed these characteristics at a Cardiac Center in Riyadh, Saudi Arabia over a period of 5 years. METHODS: This retrospective study was done on all infective endocarditis (IE) patients admitted to Prince Sultan Cardiac Center between January 1, 2015, and December 31, 2019. Clinical characteristics, microbiological results, management, and outcomes were assessed. RESULT: A total of 340 cases of infective endocarditis were identified over the study period. Most patients (64%) were 50 years old or above, and 67% were males. Fever was the most common clinical presentation, and a murmur was audible in a fifth of patients. Blood cultures were positive in 177 (52%) cases. The most common organisms were Staphylococcus aureus, coagulase negative Staphylococcus and viridans group Streptococcus. Most common microbiological organisms causing native valve endocarditis were viridans group Streptococcus (32%) followed by methicillin-susceptible Staphylococcus aureus (21%), and for prosthetic valve endocarditis they were coagulase negative Staphylococcus (32%) followed by methicillin-susceptible Staphylococcus aureus (23%), the most common causes of culture negative endocarditis were Q-fever and brucellosis. Predisposing cardiac conditions were present in 127 (37%) patients, most commonly rheumatic heart disease and congenital heart disease. Surgical intervention was done in 26% of cases, with an overall in-hospital mortality rate of 6.76%. CONCLUSION: We demonstrate the epidemiological, clinical, and microbiological profile of infective endocarditis in a tertiary care cardiac center in Saudi Arabia. It gives information concerning the prevalence of responsible organisms. This information will be helpful in assessing patients with suspected IE and in planning management of cases knowing the relative frequency of types of microorganisms encountered. Springer Netherlands 2021-11-04 /pmc/articles/PMC8664328/ /pubmed/34735715 http://dx.doi.org/10.1007/s44197-021-00013-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Article Barry, Mazin Bari, Syed Abdul Akhtar, Muhammad Yasin Al Nahdi, Faizah Erlandez, Richilda Al Khushail, Abdullah Al Hebaishi, Yahya Clinical and Microbiological Characteristics of Infective Endocarditis at a Cardiac Center in Saudi Arabia |
title | Clinical and Microbiological Characteristics of Infective Endocarditis at a Cardiac Center in Saudi Arabia |
title_full | Clinical and Microbiological Characteristics of Infective Endocarditis at a Cardiac Center in Saudi Arabia |
title_fullStr | Clinical and Microbiological Characteristics of Infective Endocarditis at a Cardiac Center in Saudi Arabia |
title_full_unstemmed | Clinical and Microbiological Characteristics of Infective Endocarditis at a Cardiac Center in Saudi Arabia |
title_short | Clinical and Microbiological Characteristics of Infective Endocarditis at a Cardiac Center in Saudi Arabia |
title_sort | clinical and microbiological characteristics of infective endocarditis at a cardiac center in saudi arabia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664328/ https://www.ncbi.nlm.nih.gov/pubmed/34735715 http://dx.doi.org/10.1007/s44197-021-00013-5 |
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