A synthetic lethal screen identifies HDAC4 as a potential target in MELK overexpressing cancers

Maternal embryonic leucine zipper kinase (MELK) is frequently overexpressed in cancer, but the role of MELK in cancer is still poorly understood. MELK was shown to have roles in many cancer-associated processes including tumor growth, chemotherapy resistance, and tumor recurrence. To determine wheth...

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Detalles Bibliográficos
Autores principales: Zhou, Lin, Zheng, Siqi, Rosas Bringas, Fernando R, Bakker, Bjorn, Simon, Judith E, Bakker, Petra L, Kazemier, Hinke G, Schubert, Michael, Roorda, Maurits, van Vugt, Marcel A T M, Chang, Michael, Foijer, Floris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664443/
https://www.ncbi.nlm.nih.gov/pubmed/34550356
http://dx.doi.org/10.1093/g3journal/jkab335

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