Effects of Lipid Overload on Heart in Metabolic Diseases

Metabolic diseases are often associated with lipid and glucose metabolism abnormalities, which increase the risk of cardiovascular disease. Diabetic cardiomyopathy (DCM) is an important development of metabolic diseases and a major cause of death. Lipids are the main fuel for energy metabolism in th...

Descripción completa

Detalles Bibliográficos
Autores principales: Yan, An, Xie, Guinan, Ding, Xinya, Wang, Yi, Guo, Liping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664556/
https://www.ncbi.nlm.nih.gov/pubmed/34891207
http://dx.doi.org/10.1055/a-1693-8356
_version_ 1784613868698337280
author Yan, An
Xie, Guinan
Ding, Xinya
Wang, Yi
Guo, Liping
author_facet Yan, An
Xie, Guinan
Ding, Xinya
Wang, Yi
Guo, Liping
author_sort Yan, An
collection PubMed
description Metabolic diseases are often associated with lipid and glucose metabolism abnormalities, which increase the risk of cardiovascular disease. Diabetic cardiomyopathy (DCM) is an important development of metabolic diseases and a major cause of death. Lipids are the main fuel for energy metabolism in the heart. The increase of circulating lipids affects the uptake and utilization of fatty acids and glucose in the heart, and also affects mitochondrial function. In this paper, the mechanism of lipid overload in metabolic diseases leading to cardiac energy metabolism disorder is discussed.
format Online
Article
Text
id pubmed-8664556
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Georg Thieme Verlag
record_format MEDLINE/PubMed
spelling pubmed-86645562021-12-13 Effects of Lipid Overload on Heart in Metabolic Diseases Yan, An Xie, Guinan Ding, Xinya Wang, Yi Guo, Liping Horm Metab Res Metabolic diseases are often associated with lipid and glucose metabolism abnormalities, which increase the risk of cardiovascular disease. Diabetic cardiomyopathy (DCM) is an important development of metabolic diseases and a major cause of death. Lipids are the main fuel for energy metabolism in the heart. The increase of circulating lipids affects the uptake and utilization of fatty acids and glucose in the heart, and also affects mitochondrial function. In this paper, the mechanism of lipid overload in metabolic diseases leading to cardiac energy metabolism disorder is discussed. Georg Thieme Verlag 2021-12-10 /pmc/articles/PMC8664556/ /pubmed/34891207 http://dx.doi.org/10.1055/a-1693-8356 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Yan, An
Xie, Guinan
Ding, Xinya
Wang, Yi
Guo, Liping
Effects of Lipid Overload on Heart in Metabolic Diseases
title Effects of Lipid Overload on Heart in Metabolic Diseases
title_full Effects of Lipid Overload on Heart in Metabolic Diseases
title_fullStr Effects of Lipid Overload on Heart in Metabolic Diseases
title_full_unstemmed Effects of Lipid Overload on Heart in Metabolic Diseases
title_short Effects of Lipid Overload on Heart in Metabolic Diseases
title_sort effects of lipid overload on heart in metabolic diseases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664556/
https://www.ncbi.nlm.nih.gov/pubmed/34891207
http://dx.doi.org/10.1055/a-1693-8356
work_keys_str_mv AT yanan effectsoflipidoverloadonheartinmetabolicdiseases
AT xieguinan effectsoflipidoverloadonheartinmetabolicdiseases
AT dingxinya effectsoflipidoverloadonheartinmetabolicdiseases
AT wangyi effectsoflipidoverloadonheartinmetabolicdiseases
AT guoliping effectsoflipidoverloadonheartinmetabolicdiseases

Ejemplares similares