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An Exploratory Review of Potential Adjunct Therapies for the Treatment of Coronavirus Infections

OBJECTIVE: The purpose of this exploratory review was to examine vitamin D, zinc, vitamin A, elderberry (Sambucus nigra), garlic (Allium sativum), licorice (Glycyrrhiza glabra), stinging nettle (Urtica dioica), N-acetylcysteine, quercetin, and selenium as potential adjunct therapies for the treatmen...

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Autores principales: Martin, Brett R., Richardson, Joshua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664662/
https://www.ncbi.nlm.nih.gov/pubmed/34924893
http://dx.doi.org/10.1016/j.jcm.2021.12.005
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author Martin, Brett R.
Richardson, Joshua
author_facet Martin, Brett R.
Richardson, Joshua
author_sort Martin, Brett R.
collection PubMed
description OBJECTIVE: The purpose of this exploratory review was to examine vitamin D, zinc, vitamin A, elderberry (Sambucus nigra), garlic (Allium sativum), licorice (Glycyrrhiza glabra), stinging nettle (Urtica dioica), N-acetylcysteine, quercetin, and selenium as potential adjunct therapies for the treatment of coronavirus infections. METHODS: A search of PubMed was performed for articles published from 2005 to 2021. Keywords searched were “zinc,” “vitamin A,” “vitamin D,” “Sambucus nigra,” “Allium sativum,” “Glycyrrhiza glabra,” “Urtica dioica,” “N-acetylcysteine,” “quercetin,” “selenium,” and “coronavirus.” RESULTS: There were 47 articles selected for this review. Findings included that vitamin D, zinc, vitamin A, S. nigra, A. sativum, G. glabra, U. dioica, N-acetylcysteine, quercetin, and selenium have been shown to produce antiinflammatory, immunostimulatory, or antiviral effects that may enhance the actions of standard therapeutics for the treatment of coronavirus infections. Specific to effects against COVID-19, we found research articles related to the effects of only vitamin D, zinc, G. glabra, quercetin, and selenium. CONCLUSION: We identified nonpharmaceutical supplements (vitamin D, zinc, vitamin A, S. nigra, A. sativum, G. glabra, and U. dioica) which may have potential to provide support for those with coronavirus infections. However, rigorous clinical studies need to be performed before any clinical recommendations can be made.
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spelling pubmed-86646622021-12-14 An Exploratory Review of Potential Adjunct Therapies for the Treatment of Coronavirus Infections Martin, Brett R. Richardson, Joshua J Chiropr Med Original Research OBJECTIVE: The purpose of this exploratory review was to examine vitamin D, zinc, vitamin A, elderberry (Sambucus nigra), garlic (Allium sativum), licorice (Glycyrrhiza glabra), stinging nettle (Urtica dioica), N-acetylcysteine, quercetin, and selenium as potential adjunct therapies for the treatment of coronavirus infections. METHODS: A search of PubMed was performed for articles published from 2005 to 2021. Keywords searched were “zinc,” “vitamin A,” “vitamin D,” “Sambucus nigra,” “Allium sativum,” “Glycyrrhiza glabra,” “Urtica dioica,” “N-acetylcysteine,” “quercetin,” “selenium,” and “coronavirus.” RESULTS: There were 47 articles selected for this review. Findings included that vitamin D, zinc, vitamin A, S. nigra, A. sativum, G. glabra, U. dioica, N-acetylcysteine, quercetin, and selenium have been shown to produce antiinflammatory, immunostimulatory, or antiviral effects that may enhance the actions of standard therapeutics for the treatment of coronavirus infections. Specific to effects against COVID-19, we found research articles related to the effects of only vitamin D, zinc, G. glabra, quercetin, and selenium. CONCLUSION: We identified nonpharmaceutical supplements (vitamin D, zinc, vitamin A, S. nigra, A. sativum, G. glabra, and U. dioica) which may have potential to provide support for those with coronavirus infections. However, rigorous clinical studies need to be performed before any clinical recommendations can be made. Elsevier 2021-12 2021-12-11 /pmc/articles/PMC8664662/ /pubmed/34924893 http://dx.doi.org/10.1016/j.jcm.2021.12.005 Text en © 2022 by National University of Health Sciences.
spellingShingle Original Research
Martin, Brett R.
Richardson, Joshua
An Exploratory Review of Potential Adjunct Therapies for the Treatment of Coronavirus Infections
title An Exploratory Review of Potential Adjunct Therapies for the Treatment of Coronavirus Infections
title_full An Exploratory Review of Potential Adjunct Therapies for the Treatment of Coronavirus Infections
title_fullStr An Exploratory Review of Potential Adjunct Therapies for the Treatment of Coronavirus Infections
title_full_unstemmed An Exploratory Review of Potential Adjunct Therapies for the Treatment of Coronavirus Infections
title_short An Exploratory Review of Potential Adjunct Therapies for the Treatment of Coronavirus Infections
title_sort exploratory review of potential adjunct therapies for the treatment of coronavirus infections
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664662/
https://www.ncbi.nlm.nih.gov/pubmed/34924893
http://dx.doi.org/10.1016/j.jcm.2021.12.005
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