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KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma

The H3K27me2/me3 histone demethylase KDM6B is essential to neuroblastoma cell survival. However, the mechanism of KDM6B action remains poorly defined. We demonstrate that inhibition of KDM6B activity 1) reduces the chromatin accessibility of E2F target genes and MYCN, 2) selectively leads to an incr...

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Detalles Bibliográficos
Autores principales:	D’Oto, Alexandra, Fang, Jie, Jin, Hongjian, Xu, Beisi, Singh, Shivendra, Mullasseril, Anoushka, Jones, Victoria, Abu-Zaid, Ahmed, von Buttlar, Xinyu, Cooke, Bailey, Hu, Dongli, Shohet, Jason, Murphy, Andrew J., Davidoff, Andrew M., Yang, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664842/ https://www.ncbi.nlm.nih.gov/pubmed/34893606 http://dx.doi.org/10.1038/s41467-021-27502-2

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