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Design, synthesis, and biological evaluation of novel urolithins derivatives as potential phosphodiesterase II inhibitors
A series of urolithins derivatives were designed and synthesized, and their structures have been confirmed by (1)H NMR, (13)C NMR, and HR-MS. The inhibitory activity of these derivatives on phosphodiesterase II (PDE2) was thoroughly studied with 3-hydroxy-8-methyl-6H-benzo[C]chromen-6-one and 3-hydr...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664850/ https://www.ncbi.nlm.nih.gov/pubmed/34893678 http://dx.doi.org/10.1038/s41598-021-03194-y |