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Pyroptosis-Related Gene Signature Is a Novel Prognostic Biomarker for Sarcoma Patients
Sarcoma is a rare and an extremely aggressive form of cancer that originates from mesenchymal cells. Pyroptosis exerts a dual effect on tumours by inhibiting tumour cell proliferation while creating a microenvironment suitable for tumour cell development and proliferation. However, the significance...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665299/ https://www.ncbi.nlm.nih.gov/pubmed/34904022 http://dx.doi.org/10.1155/2021/9919842 |
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author | Wei, Dalong Lan, Xiaoling Huang, Zhiqun Tang, Qiang Wang, Zechen Ma, Yanfei Wei, Liuzhi Wei, Qiuju Zhao, Jingjie Shen, Jiajia He, Siyuan Song, Jian Meng, Lingzhang Tang, Qianli |
author_facet | Wei, Dalong Lan, Xiaoling Huang, Zhiqun Tang, Qiang Wang, Zechen Ma, Yanfei Wei, Liuzhi Wei, Qiuju Zhao, Jingjie Shen, Jiajia He, Siyuan Song, Jian Meng, Lingzhang Tang, Qianli |
author_sort | Wei, Dalong |
collection | PubMed |
description | Sarcoma is a rare and an extremely aggressive form of cancer that originates from mesenchymal cells. Pyroptosis exerts a dual effect on tumours by inhibiting tumour cell proliferation while creating a microenvironment suitable for tumour cell development and proliferation. However, the significance of pyroptosis-related gene (PRG) expression in sarcoma has not yet been evaluated. Here, we conduct a retrospective analysis to examine PRG expression in 256 sarcoma samples from The Cancer Genome Atlas database. We identified the PRGs that had a significant correlation with overall patient survival in sarcoma by performing a univariate Cox regression analysis. Subsequently, we conducted a LASSO regression analysis and created a risk model for a six-PRG signature. As indicated from the Kaplan–Meier analysis, this signature revealed a significant difference between high- and low-risk sarcoma patients. A receiver operating characteristic curve analysis confirmed that this signature could predict overall patient survival in sarcoma patients with high sensitivity and specificity. Gene ontology annotation and Kyoto Encyclopaedia of Genes and Genomes pathway enrichment analyses revealed that five independent PRGs were closely associated with increased immune activity. Moreover, we also deciphered that increased number of immune cells infiltrated the tumour microenvironment in sarcoma. In brief, the PRG signature can effectively act as novel prognostic biomarker for sarcoma patients and is associated with the tumour immune microenvironment. |
format | Online Article Text |
id | pubmed-8665299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-86652992021-12-12 Pyroptosis-Related Gene Signature Is a Novel Prognostic Biomarker for Sarcoma Patients Wei, Dalong Lan, Xiaoling Huang, Zhiqun Tang, Qiang Wang, Zechen Ma, Yanfei Wei, Liuzhi Wei, Qiuju Zhao, Jingjie Shen, Jiajia He, Siyuan Song, Jian Meng, Lingzhang Tang, Qianli Dis Markers Research Article Sarcoma is a rare and an extremely aggressive form of cancer that originates from mesenchymal cells. Pyroptosis exerts a dual effect on tumours by inhibiting tumour cell proliferation while creating a microenvironment suitable for tumour cell development and proliferation. However, the significance of pyroptosis-related gene (PRG) expression in sarcoma has not yet been evaluated. Here, we conduct a retrospective analysis to examine PRG expression in 256 sarcoma samples from The Cancer Genome Atlas database. We identified the PRGs that had a significant correlation with overall patient survival in sarcoma by performing a univariate Cox regression analysis. Subsequently, we conducted a LASSO regression analysis and created a risk model for a six-PRG signature. As indicated from the Kaplan–Meier analysis, this signature revealed a significant difference between high- and low-risk sarcoma patients. A receiver operating characteristic curve analysis confirmed that this signature could predict overall patient survival in sarcoma patients with high sensitivity and specificity. Gene ontology annotation and Kyoto Encyclopaedia of Genes and Genomes pathway enrichment analyses revealed that five independent PRGs were closely associated with increased immune activity. Moreover, we also deciphered that increased number of immune cells infiltrated the tumour microenvironment in sarcoma. In brief, the PRG signature can effectively act as novel prognostic biomarker for sarcoma patients and is associated with the tumour immune microenvironment. Hindawi 2021-12-03 /pmc/articles/PMC8665299/ /pubmed/34904022 http://dx.doi.org/10.1155/2021/9919842 Text en Copyright © 2021 Dalong Wei et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wei, Dalong Lan, Xiaoling Huang, Zhiqun Tang, Qiang Wang, Zechen Ma, Yanfei Wei, Liuzhi Wei, Qiuju Zhao, Jingjie Shen, Jiajia He, Siyuan Song, Jian Meng, Lingzhang Tang, Qianli Pyroptosis-Related Gene Signature Is a Novel Prognostic Biomarker for Sarcoma Patients |
title | Pyroptosis-Related Gene Signature Is a Novel Prognostic Biomarker for Sarcoma Patients |
title_full | Pyroptosis-Related Gene Signature Is a Novel Prognostic Biomarker for Sarcoma Patients |
title_fullStr | Pyroptosis-Related Gene Signature Is a Novel Prognostic Biomarker for Sarcoma Patients |
title_full_unstemmed | Pyroptosis-Related Gene Signature Is a Novel Prognostic Biomarker for Sarcoma Patients |
title_short | Pyroptosis-Related Gene Signature Is a Novel Prognostic Biomarker for Sarcoma Patients |
title_sort | pyroptosis-related gene signature is a novel prognostic biomarker for sarcoma patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665299/ https://www.ncbi.nlm.nih.gov/pubmed/34904022 http://dx.doi.org/10.1155/2021/9919842 |
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