Quantitative Ubiquitylome Analysis Reveals the Specificity of RNF111/Arkadia E3 Ubiquitin Ligase for its Degradative Substrates SKI and SKIL/SnoN in TGF-β Signaling Pathway

RNF111/Arkadia is an E3 ubiquitin ligase that activates the transforming growth factor-β (TGF-β) pathway by degrading transcriptional repressors SKIL/SnoN and SKI. Truncations of the RING C-terminal domain of RNF111 that abolish its E3 function and subsequently activate TGF-β signaling are observed...

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Detalles Bibliográficos
Autores principales: Laigle, Victor, Dingli, Florent, Amhaz, Sadek, Perron, Tiphaine, Chouchène, Mouna, Colasse, Sabrina, Petit, Isabelle, Poullet, Patrick, Loew, Damarys, Prunier, Céline, Levy, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665411/
https://www.ncbi.nlm.nih.gov/pubmed/34740826
http://dx.doi.org/10.1016/j.mcpro.2021.100173

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