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Evaluation of the current bacteriological profile and antibiotic sensitivity pattern in chronic suppurative otitis media
OBJECTIVE: To determine the current microbiological profile of chronic suppurative otitis media (CSOM), their antimicrobial sensitivity, their resistance pattern to locally available antibiotics and the appropriate antibiotic against isolated microorganisms causing CSOM. METHODS: This cross‐sectiona...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665472/ https://www.ncbi.nlm.nih.gov/pubmed/34938866 http://dx.doi.org/10.1002/lio2.682 |
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author | Wan Draman, Wan Nur Anis Md Daud, Mohd Khairi Mohamad, Hazama Hassan, Siti Asma Abd Rahman, Normastura |
author_facet | Wan Draman, Wan Nur Anis Md Daud, Mohd Khairi Mohamad, Hazama Hassan, Siti Asma Abd Rahman, Normastura |
author_sort | Wan Draman, Wan Nur Anis |
collection | PubMed |
description | OBJECTIVE: To determine the current microbiological profile of chronic suppurative otitis media (CSOM), their antimicrobial sensitivity, their resistance pattern to locally available antibiotics and the appropriate antibiotic against isolated microorganisms causing CSOM. METHODS: This cross‐sectional study involved 91 ear swab specimens obtained from patients clinically diagnosed with active CSOM. Swabs were cultured for microbial identification according to a standard protocol. We performed antibiotic susceptibility testing, using the modified Kirby‐Bauer disc diffusion method, and the diameter of the inhibition zone was interpreted based Clinical Laboratory Standards Institute guidelines. RESULTS: Microbial growth was seen in 85 (93.4%) samples, but 6 (6.6%) samples had no growth. Among the samples with growth, 63 (69.2%) were monomicrobial, 13 (14.3%) were polymicrobial, and 9 (9.9%) were of mixed growth with more than three microorganisms. The most common bacteria isolated was Pseudomonas aeruginosa (32.6%) followed by Staphylococcus aureus (16.9%) and Klebsiella spp. (5.6%). The most sensitive antibiotics against P aeruginosa were ceftazidime, meropenem, piperacillin‐tazobactam, and cefepime. S aureus showed the highest sensitivity toward rifampin, cefoxitin, and fusidic acid. CONCLUSIONS: The bacteriological profile of CSOM showed a high prevalence of P aeruginosa, followed by S aureus and Klebsiella spp. with different distributions in different age groups. We observed a declining pattern of their antibiotic sensitivity. It is important to be aware of the current trend of the bacteriological profiles and to revise the antibiotic regime according to both the sensitivity and age groups. Level of Evidence: NA. |
format | Online Article Text |
id | pubmed-8665472 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86654722021-12-21 Evaluation of the current bacteriological profile and antibiotic sensitivity pattern in chronic suppurative otitis media Wan Draman, Wan Nur Anis Md Daud, Mohd Khairi Mohamad, Hazama Hassan, Siti Asma Abd Rahman, Normastura Laryngoscope Investig Otolaryngol Comprehensive (General) Otolaryngology OBJECTIVE: To determine the current microbiological profile of chronic suppurative otitis media (CSOM), their antimicrobial sensitivity, their resistance pattern to locally available antibiotics and the appropriate antibiotic against isolated microorganisms causing CSOM. METHODS: This cross‐sectional study involved 91 ear swab specimens obtained from patients clinically diagnosed with active CSOM. Swabs were cultured for microbial identification according to a standard protocol. We performed antibiotic susceptibility testing, using the modified Kirby‐Bauer disc diffusion method, and the diameter of the inhibition zone was interpreted based Clinical Laboratory Standards Institute guidelines. RESULTS: Microbial growth was seen in 85 (93.4%) samples, but 6 (6.6%) samples had no growth. Among the samples with growth, 63 (69.2%) were monomicrobial, 13 (14.3%) were polymicrobial, and 9 (9.9%) were of mixed growth with more than three microorganisms. The most common bacteria isolated was Pseudomonas aeruginosa (32.6%) followed by Staphylococcus aureus (16.9%) and Klebsiella spp. (5.6%). The most sensitive antibiotics against P aeruginosa were ceftazidime, meropenem, piperacillin‐tazobactam, and cefepime. S aureus showed the highest sensitivity toward rifampin, cefoxitin, and fusidic acid. CONCLUSIONS: The bacteriological profile of CSOM showed a high prevalence of P aeruginosa, followed by S aureus and Klebsiella spp. with different distributions in different age groups. We observed a declining pattern of their antibiotic sensitivity. It is important to be aware of the current trend of the bacteriological profiles and to revise the antibiotic regime according to both the sensitivity and age groups. Level of Evidence: NA. John Wiley & Sons, Inc. 2021-10-18 /pmc/articles/PMC8665472/ /pubmed/34938866 http://dx.doi.org/10.1002/lio2.682 Text en © 2021 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Comprehensive (General) Otolaryngology Wan Draman, Wan Nur Anis Md Daud, Mohd Khairi Mohamad, Hazama Hassan, Siti Asma Abd Rahman, Normastura Evaluation of the current bacteriological profile and antibiotic sensitivity pattern in chronic suppurative otitis media |
title | Evaluation of the current bacteriological profile and antibiotic sensitivity pattern in chronic suppurative otitis media |
title_full | Evaluation of the current bacteriological profile and antibiotic sensitivity pattern in chronic suppurative otitis media |
title_fullStr | Evaluation of the current bacteriological profile and antibiotic sensitivity pattern in chronic suppurative otitis media |
title_full_unstemmed | Evaluation of the current bacteriological profile and antibiotic sensitivity pattern in chronic suppurative otitis media |
title_short | Evaluation of the current bacteriological profile and antibiotic sensitivity pattern in chronic suppurative otitis media |
title_sort | evaluation of the current bacteriological profile and antibiotic sensitivity pattern in chronic suppurative otitis media |
topic | Comprehensive (General) Otolaryngology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665472/ https://www.ncbi.nlm.nih.gov/pubmed/34938866 http://dx.doi.org/10.1002/lio2.682 |
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