Integrated proteogenomic analysis revealed the metabolic heterogeneity in noncancerous liver tissues of patients with hepatocellular carcinoma

Understanding the adjacent liver microenvironment of hepatocellular carcinoma (HCC) with possible metastasis tendency might provide a strategy for risk classification of patients and potential therapies by converting the unique metastasis-inclined microenvironment to a metastasis-averse one. In this...

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Autores principales: Liao, Haotian, Du, Jinpeng, Wang, Haichuan, Lan, Tian, Peng, Jiajie, Wu, Zhenru, Yuan, Kefei, Zeng, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665512/
https://www.ncbi.nlm.nih.gov/pubmed/34895304
http://dx.doi.org/10.1186/s13045-021-01195-y
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author Liao, Haotian
Du, Jinpeng
Wang, Haichuan
Lan, Tian
Peng, Jiajie
Wu, Zhenru
Yuan, Kefei
Zeng, Yong
author_facet Liao, Haotian
Du, Jinpeng
Wang, Haichuan
Lan, Tian
Peng, Jiajie
Wu, Zhenru
Yuan, Kefei
Zeng, Yong
author_sort Liao, Haotian
collection PubMed
description Understanding the adjacent liver microenvironment of hepatocellular carcinoma (HCC) with possible metastasis tendency might provide a strategy for risk classification of patients and potential therapies by converting the unique metastasis-inclined microenvironment to a metastasis-averse one. In this study, we performed an integrated proteogenomic analysis to have a comprehensive view on the heterogeneity of hepatic microenvironment contributing to HCC metastasis. Pairing mRNA-protein analysis revealed consistent and discordant mRNA-protein expressions in metabolism regulations and cancer-related pathways, respectively. Proteomic profiling identified three subgroups associated with the recurrence-free survival of patients. These proteomic subgroups demonstrated distinct features in metabolic reprogramming, which was potentially modified by epigenetic alterations. This study raises the point of metabolic heterogeneity in HCC noncancerous tissues and may offer a new perspective on HCC treatment. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13045-021-01195-y.
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spelling pubmed-86655122021-12-13 Integrated proteogenomic analysis revealed the metabolic heterogeneity in noncancerous liver tissues of patients with hepatocellular carcinoma Liao, Haotian Du, Jinpeng Wang, Haichuan Lan, Tian Peng, Jiajie Wu, Zhenru Yuan, Kefei Zeng, Yong J Hematol Oncol Letter to the Editor Understanding the adjacent liver microenvironment of hepatocellular carcinoma (HCC) with possible metastasis tendency might provide a strategy for risk classification of patients and potential therapies by converting the unique metastasis-inclined microenvironment to a metastasis-averse one. In this study, we performed an integrated proteogenomic analysis to have a comprehensive view on the heterogeneity of hepatic microenvironment contributing to HCC metastasis. Pairing mRNA-protein analysis revealed consistent and discordant mRNA-protein expressions in metabolism regulations and cancer-related pathways, respectively. Proteomic profiling identified three subgroups associated with the recurrence-free survival of patients. These proteomic subgroups demonstrated distinct features in metabolic reprogramming, which was potentially modified by epigenetic alterations. This study raises the point of metabolic heterogeneity in HCC noncancerous tissues and may offer a new perspective on HCC treatment. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13045-021-01195-y. BioMed Central 2021-12-11 /pmc/articles/PMC8665512/ /pubmed/34895304 http://dx.doi.org/10.1186/s13045-021-01195-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Liao, Haotian
Du, Jinpeng
Wang, Haichuan
Lan, Tian
Peng, Jiajie
Wu, Zhenru
Yuan, Kefei
Zeng, Yong
Integrated proteogenomic analysis revealed the metabolic heterogeneity in noncancerous liver tissues of patients with hepatocellular carcinoma
title Integrated proteogenomic analysis revealed the metabolic heterogeneity in noncancerous liver tissues of patients with hepatocellular carcinoma
title_full Integrated proteogenomic analysis revealed the metabolic heterogeneity in noncancerous liver tissues of patients with hepatocellular carcinoma
title_fullStr Integrated proteogenomic analysis revealed the metabolic heterogeneity in noncancerous liver tissues of patients with hepatocellular carcinoma
title_full_unstemmed Integrated proteogenomic analysis revealed the metabolic heterogeneity in noncancerous liver tissues of patients with hepatocellular carcinoma
title_short Integrated proteogenomic analysis revealed the metabolic heterogeneity in noncancerous liver tissues of patients with hepatocellular carcinoma
title_sort integrated proteogenomic analysis revealed the metabolic heterogeneity in noncancerous liver tissues of patients with hepatocellular carcinoma
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665512/
https://www.ncbi.nlm.nih.gov/pubmed/34895304
http://dx.doi.org/10.1186/s13045-021-01195-y
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