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Update on pathogenesis and diagnosis flow of normoalbuminuric diabetes with renal insufficiency
In recent decades, the prevalence of diabetic kidney disease has remained stable and appears to be a wide heterogeneity. Normoalbuminuric diabetes with renal insufficiency, which is characterized by a decline in the glomerular filtration rate in the absence of albuminuria, has been identified as an...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665546/ https://www.ncbi.nlm.nih.gov/pubmed/34895352 http://dx.doi.org/10.1186/s40001-021-00612-9 |
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author | Deng, Le Li, Wenjie Xu, Gaosi |
author_facet | Deng, Le Li, Wenjie Xu, Gaosi |
author_sort | Deng, Le |
collection | PubMed |
description | In recent decades, the prevalence of diabetic kidney disease has remained stable and appears to be a wide heterogeneity. Normoalbuminuric diabetes with renal insufficiency, which is characterized by a decline in the glomerular filtration rate in the absence of albuminuria, has been identified as an albuminuria-independent phenotype of diabetic kidney disease. Epidemiological data demonstrate that normoalbuminuric phenotype is prevalent. Compared to albuminuric phenotype, normoalbuminuric phenotype has distinct clinical characteristics and a wide heterogeneity of pathological features. Currently, the pathogenesis of normoalbuminuric phenotype remains unclear. Additionally, the flow of diagnosing normoalbuminuric phenotype is not perfect. In this article, we review the latest studies addressing the epidemiology, clinical characteristics, and pathology of normoalbuminuric phenotype. Based on the studies of clinical features and renal histopathologic changes, we attempt to propose an underlying pathogenesis model and a flow chart for diagnosing normoalbuminuric phenotype. |
format | Online Article Text |
id | pubmed-8665546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-86655462021-12-13 Update on pathogenesis and diagnosis flow of normoalbuminuric diabetes with renal insufficiency Deng, Le Li, Wenjie Xu, Gaosi Eur J Med Res Review In recent decades, the prevalence of diabetic kidney disease has remained stable and appears to be a wide heterogeneity. Normoalbuminuric diabetes with renal insufficiency, which is characterized by a decline in the glomerular filtration rate in the absence of albuminuria, has been identified as an albuminuria-independent phenotype of diabetic kidney disease. Epidemiological data demonstrate that normoalbuminuric phenotype is prevalent. Compared to albuminuric phenotype, normoalbuminuric phenotype has distinct clinical characteristics and a wide heterogeneity of pathological features. Currently, the pathogenesis of normoalbuminuric phenotype remains unclear. Additionally, the flow of diagnosing normoalbuminuric phenotype is not perfect. In this article, we review the latest studies addressing the epidemiology, clinical characteristics, and pathology of normoalbuminuric phenotype. Based on the studies of clinical features and renal histopathologic changes, we attempt to propose an underlying pathogenesis model and a flow chart for diagnosing normoalbuminuric phenotype. BioMed Central 2021-12-11 /pmc/articles/PMC8665546/ /pubmed/34895352 http://dx.doi.org/10.1186/s40001-021-00612-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Deng, Le Li, Wenjie Xu, Gaosi Update on pathogenesis and diagnosis flow of normoalbuminuric diabetes with renal insufficiency |
title | Update on pathogenesis and diagnosis flow of normoalbuminuric diabetes with renal insufficiency |
title_full | Update on pathogenesis and diagnosis flow of normoalbuminuric diabetes with renal insufficiency |
title_fullStr | Update on pathogenesis and diagnosis flow of normoalbuminuric diabetes with renal insufficiency |
title_full_unstemmed | Update on pathogenesis and diagnosis flow of normoalbuminuric diabetes with renal insufficiency |
title_short | Update on pathogenesis and diagnosis flow of normoalbuminuric diabetes with renal insufficiency |
title_sort | update on pathogenesis and diagnosis flow of normoalbuminuric diabetes with renal insufficiency |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665546/ https://www.ncbi.nlm.nih.gov/pubmed/34895352 http://dx.doi.org/10.1186/s40001-021-00612-9 |
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