Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology

BACKGROUND: TREM2 is a microglial receptor genetically linked to the risk for Alzheimer’s disease (AD). The cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2) have emerged as a valuable biomarker for the disease progression in AD and higher CSF levels of sTREM2 are linked to slower cognitive...

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Detalles Bibliográficos
Autores principales: Sheng, Xuan, Yao, Yunling, Huang, Ruizhi, Xu, Ying, Zhu, Yifei, Chen, Linting, Zhang, Lianshuai, Wang, Wanbing, Zhuo, Rengong, Can, Dan, Chang, Che-Feng, Zhang, Yun-wu, Xu, Huaxi, Bu, Guojun, Zhong, Li, Chen, Xiao-Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665564/
https://www.ncbi.nlm.nih.gov/pubmed/34893068
http://dx.doi.org/10.1186/s12974-021-02340-7

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