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Potential Novel Modules and Hub Genes as Prognostic Candidates of Thyroid Cancer by Weighted Gene Co-Expression Network Analysis

BACKGROUND: Although thyroid cancer (THCA) is one of the most common type of endocrine malignancy, its highly complex molecular mechanisms of carcinogenesis are not completely known. MATERIALS AND METHODS: In this study, weighted gene co-expression network analysis (WGCNA) was utilized to construct...

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Autores principales: Shi, Zhiqiang, Li, Xinghui, Zhang, Long, Luo, Yilang, Shrestha, Bikal, Hu, Xuegang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665846/
https://www.ncbi.nlm.nih.gov/pubmed/34908870
http://dx.doi.org/10.2147/IJGM.S329128
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author Shi, Zhiqiang
Li, Xinghui
Zhang, Long
Luo, Yilang
Shrestha, Bikal
Hu, Xuegang
author_facet Shi, Zhiqiang
Li, Xinghui
Zhang, Long
Luo, Yilang
Shrestha, Bikal
Hu, Xuegang
author_sort Shi, Zhiqiang
collection PubMed
description BACKGROUND: Although thyroid cancer (THCA) is one of the most common type of endocrine malignancy, its highly complex molecular mechanisms of carcinogenesis are not completely known. MATERIALS AND METHODS: In this study, weighted gene co-expression network analysis (WGCNA) was utilized to construct gene co-expression networks and evaluate the relations between modules and clinical traits to identify potential prognostic biomarkers for THCA patients. RNA-seq data and clinical data were downloaded from The Cancer Genome Atlas (TCGA). Other independent datasets from the Gene Expression Omnibus (GEO) database and the Human Protein Atlas database were performed to validate findings. RESULTS: Finally, 11 co-expression modules were constructed and four hub genes, CCDC146, SLC4A4, TDRD9 and MUM1L1, were identified and validated statistically, which were considerably interrelated to worse survival of THCA patients. CONCLUSION: This research study revealed four hub genes may be considered candidate prognostic biomarkers and potential therapeutic targets for THCA patients in the future.
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spelling pubmed-86658462021-12-13 Potential Novel Modules and Hub Genes as Prognostic Candidates of Thyroid Cancer by Weighted Gene Co-Expression Network Analysis Shi, Zhiqiang Li, Xinghui Zhang, Long Luo, Yilang Shrestha, Bikal Hu, Xuegang Int J Gen Med Original Research BACKGROUND: Although thyroid cancer (THCA) is one of the most common type of endocrine malignancy, its highly complex molecular mechanisms of carcinogenesis are not completely known. MATERIALS AND METHODS: In this study, weighted gene co-expression network analysis (WGCNA) was utilized to construct gene co-expression networks and evaluate the relations between modules and clinical traits to identify potential prognostic biomarkers for THCA patients. RNA-seq data and clinical data were downloaded from The Cancer Genome Atlas (TCGA). Other independent datasets from the Gene Expression Omnibus (GEO) database and the Human Protein Atlas database were performed to validate findings. RESULTS: Finally, 11 co-expression modules were constructed and four hub genes, CCDC146, SLC4A4, TDRD9 and MUM1L1, were identified and validated statistically, which were considerably interrelated to worse survival of THCA patients. CONCLUSION: This research study revealed four hub genes may be considered candidate prognostic biomarkers and potential therapeutic targets for THCA patients in the future. Dove 2021-12-07 /pmc/articles/PMC8665846/ /pubmed/34908870 http://dx.doi.org/10.2147/IJGM.S329128 Text en © 2021 Shi et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Shi, Zhiqiang
Li, Xinghui
Zhang, Long
Luo, Yilang
Shrestha, Bikal
Hu, Xuegang
Potential Novel Modules and Hub Genes as Prognostic Candidates of Thyroid Cancer by Weighted Gene Co-Expression Network Analysis
title Potential Novel Modules and Hub Genes as Prognostic Candidates of Thyroid Cancer by Weighted Gene Co-Expression Network Analysis
title_full Potential Novel Modules and Hub Genes as Prognostic Candidates of Thyroid Cancer by Weighted Gene Co-Expression Network Analysis
title_fullStr Potential Novel Modules and Hub Genes as Prognostic Candidates of Thyroid Cancer by Weighted Gene Co-Expression Network Analysis
title_full_unstemmed Potential Novel Modules and Hub Genes as Prognostic Candidates of Thyroid Cancer by Weighted Gene Co-Expression Network Analysis
title_short Potential Novel Modules and Hub Genes as Prognostic Candidates of Thyroid Cancer by Weighted Gene Co-Expression Network Analysis
title_sort potential novel modules and hub genes as prognostic candidates of thyroid cancer by weighted gene co-expression network analysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665846/
https://www.ncbi.nlm.nih.gov/pubmed/34908870
http://dx.doi.org/10.2147/IJGM.S329128
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