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Design, synthesis and in vitro evaluation of novel SARS-CoV-2 3CL(pro) covalent inhibitors
Severe diseases such as the ongoing COVID-19 pandemic, as well as the previous SARS and MERS outbreaks, are the result of coronavirus infections and have demonstrated the urgent need for antiviral drugs to combat these deadly viruses. Due to its essential role in viral replication and function, 3CL(...
Autores principales: | Stille, Julia K., Tjutrins, Jevgenijs, Wang, Guanyu, Venegas, Felipe A., Hennecker, Christopher, Rueda, Andrés M., Sharon, Itai, Blaine, Nicole, Miron, Caitlin E., Pinus, Sharon, Labarre, Anne, Plescia, Jessica, Burai Patrascu, Mihai, Zhang, Xiaocong, Wahba, Alexander S., Vlaho, Danielle, Huot, Mitchell J., Schmeing, T. Martin, Mittermaier, Anthony K., Moitessier, Nicolas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Masson SAS.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665847/ https://www.ncbi.nlm.nih.gov/pubmed/34995923 http://dx.doi.org/10.1016/j.ejmech.2021.114046 |
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