Cargando…

M2-Type Macrophages Induce Tregs Generation by Activating the TGF-β/Smad Signalling Pathway to Promote Colorectal Cancer Development

PURPOSE: The increase of both M2-type macrophages and Tregs is closely associated with the development of colorectal cancer. However, the mechanism of their interaction is still unclear. In this study, we investigated the correlation of M2-type macrophages with Tregs and the possible mechanisms betw...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Xueqian, Gao, Yu, Chen, Yanlei, Liu, Jinhao, Yang, Chunyu, Bao, Cuifen, Wang, Yanping, Feng, Yang, Song, Xiaoyu, Qiao, Shifeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665883/ https://www.ncbi.nlm.nih.gov/pubmed/34908844 http://dx.doi.org/10.2147/OTT.S336548

Ejemplares similares

A study of the correlation between M2 macrophages and lymph node metastasis of colorectal carcinoma
por: Wang, Yanping, et al.
Publicado: (2021)

Study of the Relationship Between Serum Amino Acid Metabolism and Lymph Node Metastasis in Patients with Colorectal Cancer
por: Liu, Jinhao, et al.
Publicado: (2020)

TGF-β/Smad3 Signals Repress Chondrocyte Hypertrophic Differentiation and Are Required for Maintaining Articular Cartilage
por: Yang, Xiao, et al.
Publicado: (2001)

Quercetin Alleviates Pulmonary Fibrosis in Silicotic Mice by Inhibiting Macrophage Transition and TGF-β-Smad2/3 Pathway
por: Geng, Fei, et al.
Publicado: (2023)

Solanine Inhibits Immune Escape Mediated by Hepatoma Treg Cells via the TGFβ/Smad Signaling Pathway
por: Gao, Juwei, et al.
Publicado: (2020)

Smad4-mediated TGF-β signaling in tumorigenesis
por: Yang, Guan, et al.
Publicado: (2010)

Celastrol inhibits colorectal cancer through TGF-β1/Smad signaling
por: Jiang, Zhitao, et al.
Publicado: (2019)

Mannan-Binding Lectin Regulates the Th17/Treg Axis Through JAK/STAT and TGF-β/SMAD Signaling Against Candida albicans Infection
por: Wang, Fanping, et al.
Publicado: (2022)

Effector Tregs: middle-men in TGFβ activation
por: Worthington, John J., et al.
Publicado: (2015)

TGF-β/Smad signaling in renal fibrosis
por: Meng, Xiao-Ming, et al.
Publicado: (2015)

Combined Treatment With TGF-β1, Retinoic Acid, and Lactoferrin Robustly Generate Inducible Tregs (iTregs) Against High Affinity Ligand
por: Jang, Young-Saeng, et al.
Publicado: (2023)

Hypoxia induces calpain activity and degrades SMAD2 to attenuate TGFβ signaling in macrophages
por: Cui, Wei, et al.
Publicado: (2015)

Focal adhesion molecule Kindlin-1 mediates activation of TGF-β signaling by interacting with TGF-βRI, SARA and Smad3 in colorectal cancer cells
por: Kong, Jinfeng, et al.
Publicado: (2016)

BAMBI regulates macrophages inducing the differentiation of Treg through the TGF-β pathway in chronic obstructive pulmonary disease
por: Sun, Sheng-Wen, et al.
Publicado: (2019)

Role of TGF-β/Smad Pathway in the Transcription of Pancreas-Specific Genes During Beta Cell Differentiation
por: Gao, Yuhua, et al.
Publicado: (2019)

The regulation of TGF-β/SMAD signaling by protein deubiquitination
por: Zhang, Juan, et al.
Publicado: (2014)

The role of TGF-β/SMAD4 signaling in cancer
por: Zhao, Ming, et al.
Publicado: (2018)

TGF-β/Smad Signaling Pathway in Tubulointerstitial Fibrosis
por: Yu, Xiao-Yong, et al.
Publicado: (2022)

TGF-β and TGF-β/Smad Signaling in the Interactions between Echinococcus multilocularis and Its Hosts
por: Wang, Junhua, et al.
Publicado: (2013)

Suppression of TGF‐β/Smad2 signaling by GW788388 enhances DENV‐2 clearance in macrophages
por: Teixeira, Gabrielly Sbano, et al.
Publicado: (2022)

TGF-β/Smad3 signalling regulates the transition of bone marrow-derived macrophages into myofibroblasts during tissue fibrosis
por: Wang, Shuang, et al.
Publicado: (2015)

SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4
por: Bertrand-Chapel, Adrien, et al.
Publicado: (2022)

Molecular mechanism of the TGF-β/Smad7 signaling pathway in ulcerative colitis
por: Bai, Bingqing, et al.
Publicado: (2022)

Intricacies of TGF-β signaling in Treg and Th17 cell biology
por: Wang, Junying, et al.
Publicado: (2023)

Corrigendum: Role of TGF-β/Smad Pathway in the Transcription of Pancreas-Specific Genes During Beta Cell Differentiation
por: Gao, Yuhua, et al.
Publicado: (2020)

SUMOylation of Smad2 mediates TGF-β-regulated endothelial–mesenchymal transition
por: Su, Qi, et al.
Publicado: (2023)

Oxymatrine inhibits the migration of human colorectal carcinoma RKO cells via inhibition of PAI-1 and the TGF-β1/Smad signaling pathway
por: Wang, Xiaoyu, et al.
Publicado: (2017)

LASP1-S100A11 axis promotes colorectal cancer aggressiveness by modulating TGFβ/Smad signaling
por: Niu, Ya, et al.
Publicado: (2016)

MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells
por: Yu, Jingyi, et al.
Publicado: (2016)

Autophagy, TGF-β, and SMAD-2/3 Signaling Regulates Interferon-β Response in Respiratory Syncytial Virus Infected Macrophages
por: Pokharel, Swechha M., et al.
Publicado: (2016)

Effect of progesterone on Smad signaling and TGF-β/Smad-regulated genes in lung epithelial cells
por: Kunzmann, Steffen, et al.
Publicado: (2018)

Oxoglaucine Suppresses Hepatic Fibrosis by Inhibiting TGFβ-Induced Smad2 Phosphorylation and ROS Generation
por: Azamov, Bakhovuddin, et al.
Publicado: (2023)

SMAD4 Feedback Activates the Canonical TGF-β Family Signaling Pathways
por: Liu, Lu, et al.
Publicado: (2021)

Gemcitabine reduces MDSCs, tregs and TGFβ-1 while restoring the teff/treg ratio in patients with pancreatic cancer
por: Eriksson, Emma, et al.
Publicado: (2016)

Diverse Roles of TGF-β/Smads in Renal Fibrosis and Inflammation
por: Lan, Hui Yao
Publicado: (2011)

Roles of TGFβ signaling Smads in squamous cell carcinoma
por: Han, Gangwen, et al.
Publicado: (2011)

Non-degradative ubiquitination in Smad-dependent TGF-β signaling
por: Tang, Liu-Ya, et al.
Publicado: (2011)

Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination
por: Xie, Feng, et al.
Publicado: (2014)

Rejuvenation by inhibiting TGF-β1/pSmad signaling
por: Corder, Elizabeth H., et al.
Publicado: (2015)

Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis
por: Walton, Kelly L., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_22u2gronb0115hp2k3u4afhmgt