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Infiltrative pattern of metastatic invasive lobular breast carcinoma in the abdomen: a pictorial review

Invasive lobular carcinoma (ILC) has a greater tendency to metastasize to the peritoneum, retroperitoneum, and gastrointestinal (GI) tract as compared to invasive carcinoma of no special type (NST). Like primary ILC in the breast, ILC metastases are frequently infiltrative and hypometabolic, rather...

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Autores principales: Wong, Ying Mei, Jagmohan, Pooja, Goh, Yong Geng, Putti, Thomas Choudary, Ow, Samuel Guan Wei, Thian, Yee Liang, Pillay, Premilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665916/
https://www.ncbi.nlm.nih.gov/pubmed/34894297
http://dx.doi.org/10.1186/s13244-021-01120-4
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author Wong, Ying Mei
Jagmohan, Pooja
Goh, Yong Geng
Putti, Thomas Choudary
Ow, Samuel Guan Wei
Thian, Yee Liang
Pillay, Premilla
author_facet Wong, Ying Mei
Jagmohan, Pooja
Goh, Yong Geng
Putti, Thomas Choudary
Ow, Samuel Guan Wei
Thian, Yee Liang
Pillay, Premilla
author_sort Wong, Ying Mei
collection PubMed
description Invasive lobular carcinoma (ILC) has a greater tendency to metastasize to the peritoneum, retroperitoneum, and gastrointestinal (GI) tract as compared to invasive carcinoma of no special type (NST). Like primary ILC in the breast, ILC metastases are frequently infiltrative and hypometabolic, rather than mass forming and hypermetabolic in nature. This renders them difficult to detect on conventional and metabolic imaging studies. As a result, intra-abdominal ILC metastases are often detected late, with patients presenting with clinical complications such as liver failure, hydronephrosis, or bowel obstruction. In patients with known history of ILC, certain imaging features are very suggestive of infiltrative metastatic ILC. These include retroperitoneal or peritoneal nodularity and linitis plastica appearance of the bowel. Recognition of linitis plastica on imaging should prompt deep or repeat biopsies. In this pictorial review, the authors aim to familiarize readers with imaging features and pitfalls for evaluation of intra-abdominal metastatic ILC. Awareness of these will allow the radiologist to assess these patients with a high index of suspicion and aid detection of metastatic disease. Also, this can direct histopathology and immunohistochemical staining to obtain the correct diagnosis in suspected metastatic disease.
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spelling pubmed-86659162021-12-27 Infiltrative pattern of metastatic invasive lobular breast carcinoma in the abdomen: a pictorial review Wong, Ying Mei Jagmohan, Pooja Goh, Yong Geng Putti, Thomas Choudary Ow, Samuel Guan Wei Thian, Yee Liang Pillay, Premilla Insights Imaging Educational Review Invasive lobular carcinoma (ILC) has a greater tendency to metastasize to the peritoneum, retroperitoneum, and gastrointestinal (GI) tract as compared to invasive carcinoma of no special type (NST). Like primary ILC in the breast, ILC metastases are frequently infiltrative and hypometabolic, rather than mass forming and hypermetabolic in nature. This renders them difficult to detect on conventional and metabolic imaging studies. As a result, intra-abdominal ILC metastases are often detected late, with patients presenting with clinical complications such as liver failure, hydronephrosis, or bowel obstruction. In patients with known history of ILC, certain imaging features are very suggestive of infiltrative metastatic ILC. These include retroperitoneal or peritoneal nodularity and linitis plastica appearance of the bowel. Recognition of linitis plastica on imaging should prompt deep or repeat biopsies. In this pictorial review, the authors aim to familiarize readers with imaging features and pitfalls for evaluation of intra-abdominal metastatic ILC. Awareness of these will allow the radiologist to assess these patients with a high index of suspicion and aid detection of metastatic disease. Also, this can direct histopathology and immunohistochemical staining to obtain the correct diagnosis in suspected metastatic disease. Springer International Publishing 2021-12-11 /pmc/articles/PMC8665916/ /pubmed/34894297 http://dx.doi.org/10.1186/s13244-021-01120-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Educational Review
Wong, Ying Mei
Jagmohan, Pooja
Goh, Yong Geng
Putti, Thomas Choudary
Ow, Samuel Guan Wei
Thian, Yee Liang
Pillay, Premilla
Infiltrative pattern of metastatic invasive lobular breast carcinoma in the abdomen: a pictorial review
title Infiltrative pattern of metastatic invasive lobular breast carcinoma in the abdomen: a pictorial review
title_full Infiltrative pattern of metastatic invasive lobular breast carcinoma in the abdomen: a pictorial review
title_fullStr Infiltrative pattern of metastatic invasive lobular breast carcinoma in the abdomen: a pictorial review
title_full_unstemmed Infiltrative pattern of metastatic invasive lobular breast carcinoma in the abdomen: a pictorial review
title_short Infiltrative pattern of metastatic invasive lobular breast carcinoma in the abdomen: a pictorial review
title_sort infiltrative pattern of metastatic invasive lobular breast carcinoma in the abdomen: a pictorial review
topic Educational Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665916/
https://www.ncbi.nlm.nih.gov/pubmed/34894297
http://dx.doi.org/10.1186/s13244-021-01120-4
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