Cargando…

CD82 protects against glaucomatous axonal transport deficits via mTORC1 activation in mice

Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by progressive optic nerve degeneration and retinal ganglion cell loss. Axonal transport deficits have been demonstrated to be the earliest crucial pathophysiological changes underlying axonal degeneration in glauco...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ye, Meng, Huang, Jingqiu, Mou, Qianxue, Luo, Jing, Hu, Yuanyuan, Lou, Xiaotong, Yao, Ke, Zhao, Bowen, Duan, Qiming, Li, Xing, Zhang, Hong, Zhao, Yin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665930/ https://www.ncbi.nlm.nih.gov/pubmed/34897284 http://dx.doi.org/10.1038/s41419-021-04445-6

Ejemplares similares

TBK1 Knockdown Alleviates Axonal Transport Deficits in Retinal Ganglion Cells Via mTORC1 Activation in a Retinal Damage Mouse Model
por: Ye, Meng, et al.
Publicado: (2023)

Modulation of Sirt1-mTORC1 Pathway in Microglia Attenuates Retinal Ganglion Cell Loss After Optic Nerve Injury
por: Mou, Qianxue, et al.
Publicado: (2021)

Microglial SIRT1 activation attenuates synapse loss in retinal inner plexiform layer via mTORC1 inhibition
por: Yao, Ke, et al.
Publicado: (2023)

VIP Stabilizes the Cytoskeleton of Schlemm's Canal Endothelia via Reducing Caspase-3 Mediated ZO-1 Endolysosomal Degradation
por: Lou, Xiaotong, et al.
Publicado: (2021)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system
por: Miao, Linqing, et al.
Publicado: (2016)

The necessary role of mTORC1 in central nervous system axon regeneration
por: Hu, Yang
Publicado: (2015)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

Oxidative stress and epigenetics in ocular vascular aging: an updated review
por: Zhao, Bowen, et al.
Publicado: (2023)

Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma
por: Cai, Jiayang, et al.
Publicado: (2023)

c-FLIP links mTORC2 to apoptosis
por: Zhao, Liqun, et al.
Publicado: (2014)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

Regulation of Autophagy through TORC1 and mTORC1
por: Noda, Takeshi
Publicado: (2017)

Exosome Release Is Regulated by mTORC1
por: Zou, Wenchong, et al.
Publicado: (2018)

Axonal transport deficits in the pathogenesis of diabetic peripheral neuropathy
por: Yang, Cunqing, et al.
Publicado: (2023)

Glutaminolysis feeds mTORC1
por: Durán, Raúl V., et al.
Publicado: (2012)

Regulation of adiposity by mTORC1
por: Magdalon, Juliana, et al.
Publicado: (2017)

Regulation of mTORC2 Signaling
por: Fu, Wenxiang, et al.
Publicado: (2020)

mTORC2 Steals the Spotlight
por: Jansen, Laura A.
Publicado: (2020)

Something to mTORC About in NASH
por: Finck, Brian N.
Publicado: (2022)

Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot
por: Goberdhan, Deborah C.I., et al.
Publicado: (2016)

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
por: Zhu, Ping Jun, et al.
Publicado: (2018)

Development and validation of immunogenic cell death-related signature for predicting the prognosis and immune landscape of uveal melanoma
por: Hu, Yuanyuan, et al.
Publicado: (2022)

Farnesylation-defective Rheb Increases Axonal Length Independently of mTORC1 Activity in Embryonic Primary Neurons
por: Choi, Seunghyuk, et al.
Publicado: (2019)

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
por: Feldman, Morris E, et al.
Publicado: (2009)

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication
por: Kuss-Duerkop, Sharon K., et al.
Publicado: (2017)

Differential regulation of mTORC1 and mTORC2 is critical for 8-Br-cAMP-induced decidualization
por: Baek, Mi-Ock, et al.
Publicado: (2018)

Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission
por: McCabe, Matthew P, et al.
Publicado: (2020)

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
por: Gan, Wenjian, et al.
Publicado: (2020)

Hyperactivity of mTORC1 or mTORC2-dependent signaling causes epilepsy downstream of somatic PTEN loss
por: Cullen, Erin R., et al.
Publicado: (2023)

Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors
por: Burnett, G. Leslie, et al.
Publicado: (2022)

mTORC1-Mediated Angiogenesis is Required for the Development of Rosacea
por: Peng, Qinqin, et al.
Publicado: (2021)

An expanded role for mTORC1 in autophagy
por: Kim, Young-Mi, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_36u8q3h7hne876frn1miv9g6kn