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Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline

BACKGROUND: Tigecycline is a tetracycline derivative that constitutes one of the last-resort antibiotics used clinically to treat infections caused by both multiple drug-resistant (MDR) Gram-negative and Gram-positive bacteria. Resistance to this drug is often caused by chromosome-encoding mechanism...

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Detalles Bibliográficos
Autores principales:	Cheng, Qipeng, Cheung, Yanchu, Liu, Chenyu, Xiao, Qingjie, Sun, Bo, Zhou, Jiahai, Chan, Edward Wai Chi, Zhang, Rong, Chen, Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666040/ https://www.ncbi.nlm.nih.gov/pubmed/34895224 http://dx.doi.org/10.1186/s12915-021-01199-7

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