Loss of hexokinase 1 sensitizes ovarian cancer to high-dose metformin

BACKGROUND: Hexokinases (HKs) are well-studied enzymes catalyzing the first step of glycolysis. However, non-canonical regulatory roles of HKs are still incompletely understood. Here, we hypothesized that HKs comprise one of the missing links between high-dose metformin and the inhibition of the res...

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Detalles Bibliográficos
Autores principales: Šimčíková, Daniela, Gardáš, Dominik, Hložková, Kateřina, Hruda, Martin, Žáček, Petr, Rob, Lukáš, Heneberg, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666047/
https://www.ncbi.nlm.nih.gov/pubmed/34895333
http://dx.doi.org/10.1186/s40170-021-00277-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666047/
https://www.ncbi.nlm.nih.gov/pubmed/34895333
http://dx.doi.org/10.1186/s40170-021-00277-2

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