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Metformin alleviates the calcification of aortic valve interstitial cells through activating the PI3K/AKT pathway in an AMPK dependent way

BACKGROUND: Calcific aortic valve disease (CAVD) is the most prevalent valvular disease worldwide. However, no effective treatment could delay or prevent the progression of the disease due to the poor understanding of its pathological mechanism. Many studies showed that metformin exerted beneficial...

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Detalles Bibliográficos
Autores principales:	En, Qiao, Zeping, Huang, Yuetang, Wang, Xu, Wang, Wei, Wang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666063/ https://www.ncbi.nlm.nih.gov/pubmed/34895136 http://dx.doi.org/10.1186/s10020-021-00416-x

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