Cargando…

Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis

Knee osteoarthritis is the most prevalent joint disease and a frequent cause of pain, functional loss and disability. Conventional treatments have demonstrated only modest clinical benefits whereas cell-based therapies have shown encouraging results, but important details, such as dose needed, long-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lamo-Espinosa, José María, Prósper, Felipe, Blanco, Juan F., Sánchez-Guijo, Fermín, Alberca, Mercedes, García, Verónica, González-Vallinas, Margarita, García-Sancho, Javier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Commentary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666077/ https://www.ncbi.nlm.nih.gov/pubmed/34895259 http://dx.doi.org/10.1186/s12967-021-03160-2

Ejemplares similares

Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I/II)
por: Lamo-Espinosa, José M., et al.
Publicado: (2016)

Phase II multicenter randomized controlled clinical trial on the efficacy of intra-articular injection of autologous bone marrow mesenchymal stem cells with platelet rich plasma for the treatment of knee osteoarthritis
por: Lamo-Espinosa, José María, et al.
Publicado: (2020)

Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: long-term follow up of a multicenter randomized controlled clinical trial (phase I/II)
por: Lamo-Espinosa, José María, et al.
Publicado: (2018)

Endobronchial autologous bone marrow–mesenchymal stromal cells in idiopathic pulmonary fibrosis: a phase I trial
por: Campo, Arantza, et al.
Publicado: (2021)

Human Bone Marrow Mesenchymal Stromal Cells Promote Bone Regeneration in a Xenogeneic Rabbit Model: A Preclinical Study
por: Blanco, Juan Francisco, et al.
Publicado: (2018)

Transcriptomic portrait of human Mesenchymal Stromal/Stem cells isolated from bone marrow and placenta
por: Roson-Burgo, Beatriz, et al.
Publicado: (2014)

Bone regeneration with autologous adipose-derived mesenchymal stem cells: A reliable experimental model in rats
por: Barrientos, F. Javier, et al.
Publicado: (2020)

Transcriptomic profile induced in bone marrow mesenchymal stromal cells after interaction with multiple myeloma cells: implications in myeloma progression and myeloma bone disease
por: Garcia-Gomez, Antonio, et al.
Publicado: (2014)

Efficacy of Autologous Bone Marrow Concentrate for Knee Osteoarthritis with and without Adipose Graft
por: Centeno, Christopher, et al.
Publicado: (2014)

Targeting the Immune System With Mesenchymal Stromal Cell-Derived Extracellular Vesicles: What Is the Cargo's Mechanism of Action?
por: Martin-Rufino, Jorge Diego, et al.
Publicado: (2019)

Fresh autologous stromal tissue fraction for the treatment of knee osteoarthritis related pain and disability
por: Santoprete, Stefano, et al.
Publicado: (2021)

Bone Marrow Aspirate Concentrate vs Autologous Conditioned Serum in the Treatment of Knee Osteoarthritis
por: Vitali, Matteo, et al.
Publicado: (2022)

Autologous bone marrow expanded mesenchymal stem cells in patellar tendinopathy: protocol for a phase I/II, single-centre, randomized with active control PRP, double-blinded clinical trial
por: Rodas, Gil, et al.
Publicado: (2019)

Influence of HLA Matching on the Efficacy of Allogeneic Mesenchymal Stromal Cell Therapies for Osteoarthritis and Degenerative Disc Disease
por: García-Sancho, Javier, et al.
Publicado: (2017)

Autologous Adipose-Derived Tissue Stromal Vascular Fraction (AD-tSVF) for Knee Osteoarthritis †
por: Vargel, İbrahim, et al.
Publicado: (2022)

Autologous Bone Marrow-Derived Chondrocytes for Patients with Knee Osteoarthritis: A Randomized Controlled Trial
por: Sadat-Ali, Mir, et al.
Publicado: (2021)

Long-Term Results of a Phase I/II Clinical Trial of Autologous Mesenchymal Stem Cell Therapy for Femoral Head Osteonecrosis
por: Blanco, Juan F., et al.
Publicado: (2023)

Optimization of Mesenchymal Stromal Cell (MSC) Manufacturing Processes for a Better Therapeutic Outcome
por: Fernández-Santos, Maria Eugenia, et al.
Publicado: (2022)

Autologous adipose‐derived stem cells for the treatment of complex cryptoglandular perianal fistula: A randomized clinical trial with long‐term follow‐up
por: Garcia‐Arranz, Mariano, et al.
Publicado: (2019)

Characterization of freshly isolated bone marrow mesenchymal stromal cells from healthy donors and patients with multiple myeloma: transcriptional modulation of the microenvironment
por: Alameda, Daniel, et al.
Publicado: (2020)

Deciphering Master Gene Regulators and Associated Networks of Human Mesenchymal Stromal Cells
por: Sánchez-Luis, Elena, et al.
Publicado: (2020)

Autologous mesenchymal stromal cells embedded in tricalcium phosphate for posterolateral spinal fusion: results of a prospective phase I/II clinical trial with long-term follow-up
por: Blanco, Juan F., et al.
Publicado: (2019)

Percutaneous autologous bone marrow concentrate for knee osteoarthritis: patient-reported outcomes and progenitor cell content
por: Centeno, Christopher J., et al.
Publicado: (2022)

The Incorporation of Extracellular Vesicles from Mesenchymal Stromal Cells Into CD34(+) Cells Increases Their Clonogenic Capacity and Bone Marrow Lodging Ability
por: Preciado, Silvia, et al.
Publicado: (2019)

Safety and tolerability of autologous bone marrow mesenchymal stromal cells in ADPKD patients
por: Makhlough, Atieh, et al.
Publicado: (2017)

Autologous mesenchymal stem cell transplantation for spinal fusion: 10 years follow-up of a phase I/II clinical trial
por: Gomez-Ruiz, Victoria, et al.
Publicado: (2023)

Autologous mesenchymal stromal cells embedded with Tissucol Duo(®) for prevention of air leak after anatomical lung resection: results of a prospective phase I/II clinical trial with long-term follow-up
por: Jiménez, Marcelo F., et al.
Publicado: (2023)

Stromal Vascular Fraction in Osteoarthritis of the Knee
por: Jeyaraman, Madhan, et al.
Publicado: (2023)

Efficacy of autologous bone marrow mesenchymal stem cells in the treatment of knee osteoarthritis and their effects on the expression of serum TNF-α and IL-6
por: Li, Jianrui, et al.
Publicado: (2020)

Bone Marrow Mesenchymal Stem Cells for Improving Hematopoietic Function: An In Vitro and In Vivo Model. Part 2: Effect on Bone Marrow Microenvironment
por: Carrancio, Soraya, et al.
Publicado: (2011)

Insights into the human mesenchymal stromal/stem cell identity through integrative transcriptomic profiling
por: Roson-Burgo, Beatriz, et al.
Publicado: (2016)

Combined Autologous Chondrocyte and Bone Marrow Mesenchymal Stromal Cell Implantation in the Knee: An 8-year Follow Up of Two First-In-Man Cases
por: Wang, Jingsong, et al.
Publicado: (2019)

Effect of Combined Intraosseous and Intraarticular Infiltrations of Autologous Platelet-Rich Plasma on Subchondral Bone Marrow Mesenchymal Stromal Cells from Patients with Hip Osteoarthritis
por: Ganguly, Payal, et al.
Publicado: (2022)

Mesenchymal stromal cell-based therapy for cartilage regeneration in knee osteoarthritis
por: Xiang, Xiao-Na, et al.
Publicado: (2022)

Effect of Autologous Conditioned Plasma Injections in Patients With Knee Osteoarthritis
por: Korpershoek, Jasmijn V., et al.
Publicado: (2023)

Is Culture Expansion Necessary in Autologous Mesenchymal Stromal Cell Therapy to Obtain Superior Results in the Management of Knee Osteoarthritis?—Meta-Analysis of Randomized Controlled Trials
por: Muthu, Sathish, et al.
Publicado: (2021)

Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study
por: Al-Najar, Mahasen, et al.
Publicado: (2017)

Hip Preservation Surgery in Osteoarthritis Prevention: Potential Benefits of the Radiographic Angular Correction
por: Lamo-Espinosa, José M., et al.
Publicado: (2022)

Therapeutic potential of mesenchymal stromal/stem cells in critical‐care patients with systemic inflammatory response syndrome
por: Martí‐Chillón, Gerardo‐Javier, et al.
Publicado: (2023)

Stromal Vascular Fraction for Osteoarthritis of the Knee Regenerative Engineering
por: Ude, Chinedu C., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_93383tb4kgk09oprcoqfjdhpql