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TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation
Tripartite motif-containing protein 5α (TRIM5α) is a cellular antiviral restriction factor that prevents early events in retrovirus replication. The activity of TRIM5α is thought to be limited to retroviruses as a result of highly specific interactions with capsid lattices. In contrast to this curre...
Autores principales: | Chiramel, Abhilash I., Meyerson, Nicholas R., McNally, Kristin L., Broeckel, Rebecca M., Montoya, Vanessa R., Méndez-Solís, Omayra, Robertson, Shelly J., Sturdevant, Gail L., Lubick, Kirk J., Nair, Vinod, Youseff, Brian H., Ireland, Robin M., Bosio, Catharine M., Kim, Kyusik, Luban, Jeremy, Hirsch, Vanessa M., Taylor, R. Travis, Bouamr, Fadila, Sawyer, Sara L., Best, Sonja M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666140/ https://www.ncbi.nlm.nih.gov/pubmed/31189110 http://dx.doi.org/10.1016/j.celrep.2019.05.040 |
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