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A hybrid systems biology and systems pharmacology investigation of Zingerone’s effects on reconstructed human epidermal tissues

BACKGROUND: As individuals live longer, elderly populations can be expected to face issues. This pattern urges researchers to investigate the aging concept further to produce successful anti-aging agents. In the current study, the effects of Zingerone (a natural compound) on epidermal tissues were a...

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Autores principales: Amjad, Elham, Sokouti, Babak, Asnaashari, Solmaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666180/
https://www.ncbi.nlm.nih.gov/pubmed/36820091
http://dx.doi.org/10.1186/s43042-021-00204-6
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author Amjad, Elham
Sokouti, Babak
Asnaashari, Solmaz
author_facet Amjad, Elham
Sokouti, Babak
Asnaashari, Solmaz
author_sort Amjad, Elham
collection PubMed
description BACKGROUND: As individuals live longer, elderly populations can be expected to face issues. This pattern urges researchers to investigate the aging concept further to produce successful anti-aging agents. In the current study, the effects of Zingerone (a natural compound) on epidermal tissues were analyzed using a bioinformatics approach. METHODS: For this purpose, we chose the GEO dataset GSE133338 to carry out the systems biology and systems pharmacology approaches, ranging from identifying the differentially expressed genes to analyzing the gene ontology, determining similar structures of Zingerone and their features (i.e., anti-oxidant, anti-inflammatory, and skin disorders), constructing the gene–chemicals network, analyzing gene–disease relationships, and validating significant genes through the evidence presented in the literature. RESULTS: The post-processing of the microarray dataset identified thirteen essential genes among control and Zingerone-treated samples. The procedure revealed various structurally similar chemical and herbal compounds with possible skin-related effects. Additionally, we studied the relationships of differentially expressed genes with skin-related diseases and validated their direct connections with skin disorders the evidence available in the literature. Also, the analysis of the microarray profiling dataset revealed the critical role of interleukins as a part of the cytokines family on skin aging progress. CONCLUSIONS: Zingerone, and potentially any constituents of Zingerone (e.g., their similar compound scan functionality), can be used as therapeutic agents in managing skin disorders such as skin aging. However, the beneficial effects of Zingerone should be assessed in other models (i.e., human or animal) in future studies.
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spelling pubmed-86661802021-12-14 A hybrid systems biology and systems pharmacology investigation of Zingerone’s effects on reconstructed human epidermal tissues Amjad, Elham Sokouti, Babak Asnaashari, Solmaz Egypt J Med Hum Genet Research BACKGROUND: As individuals live longer, elderly populations can be expected to face issues. This pattern urges researchers to investigate the aging concept further to produce successful anti-aging agents. In the current study, the effects of Zingerone (a natural compound) on epidermal tissues were analyzed using a bioinformatics approach. METHODS: For this purpose, we chose the GEO dataset GSE133338 to carry out the systems biology and systems pharmacology approaches, ranging from identifying the differentially expressed genes to analyzing the gene ontology, determining similar structures of Zingerone and their features (i.e., anti-oxidant, anti-inflammatory, and skin disorders), constructing the gene–chemicals network, analyzing gene–disease relationships, and validating significant genes through the evidence presented in the literature. RESULTS: The post-processing of the microarray dataset identified thirteen essential genes among control and Zingerone-treated samples. The procedure revealed various structurally similar chemical and herbal compounds with possible skin-related effects. Additionally, we studied the relationships of differentially expressed genes with skin-related diseases and validated their direct connections with skin disorders the evidence available in the literature. Also, the analysis of the microarray profiling dataset revealed the critical role of interleukins as a part of the cytokines family on skin aging progress. CONCLUSIONS: Zingerone, and potentially any constituents of Zingerone (e.g., their similar compound scan functionality), can be used as therapeutic agents in managing skin disorders such as skin aging. However, the beneficial effects of Zingerone should be assessed in other models (i.e., human or animal) in future studies. Springer Berlin Heidelberg 2021-12-13 2021 /pmc/articles/PMC8666180/ /pubmed/36820091 http://dx.doi.org/10.1186/s43042-021-00204-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Amjad, Elham
Sokouti, Babak
Asnaashari, Solmaz
A hybrid systems biology and systems pharmacology investigation of Zingerone’s effects on reconstructed human epidermal tissues
title A hybrid systems biology and systems pharmacology investigation of Zingerone’s effects on reconstructed human epidermal tissues
title_full A hybrid systems biology and systems pharmacology investigation of Zingerone’s effects on reconstructed human epidermal tissues
title_fullStr A hybrid systems biology and systems pharmacology investigation of Zingerone’s effects on reconstructed human epidermal tissues
title_full_unstemmed A hybrid systems biology and systems pharmacology investigation of Zingerone’s effects on reconstructed human epidermal tissues
title_short A hybrid systems biology and systems pharmacology investigation of Zingerone’s effects on reconstructed human epidermal tissues
title_sort hybrid systems biology and systems pharmacology investigation of zingerone’s effects on reconstructed human epidermal tissues
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666180/
https://www.ncbi.nlm.nih.gov/pubmed/36820091
http://dx.doi.org/10.1186/s43042-021-00204-6
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