Paraneoplastic Polymyositis Due to Renal Cell Carcinoma in a Patient with Autosomal Dominant Polycystic Kidney Disease

We herein report a 70-year-old man with malaise and muscle weakness that had developed within a month. The patient also had abdominal fullness due to polycystic kidney disease. Severe proximal skeletal muscle weakness and mild elevation of creatinine kinase to 301 IU/L were noted. A muscle biopsy of...

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Autores principales: Noda-Narita, Shoko, Kanzaki, Mami, Uesaka, Yoshikazu, Suwabe, Tatsuya, Kinowaki, Keiichi, Marui, Yuhji, Hoshino, Junichi, Sawa, Naoki, Ubara, Yoshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666206/
https://www.ncbi.nlm.nih.gov/pubmed/34053989
http://dx.doi.org/10.2169/internalmedicine.7417-21
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author Noda-Narita, Shoko
Kanzaki, Mami
Uesaka, Yoshikazu
Suwabe, Tatsuya
Kinowaki, Keiichi
Marui, Yuhji
Hoshino, Junichi
Sawa, Naoki
Ubara, Yoshifumi
author_facet Noda-Narita, Shoko
Kanzaki, Mami
Uesaka, Yoshikazu
Suwabe, Tatsuya
Kinowaki, Keiichi
Marui, Yuhji
Hoshino, Junichi
Sawa, Naoki
Ubara, Yoshifumi
author_sort Noda-Narita, Shoko
collection PubMed
description We herein report a 70-year-old man with malaise and muscle weakness that had developed within a month. The patient also had abdominal fullness due to polycystic kidney disease. Severe proximal skeletal muscle weakness and mild elevation of creatinine kinase to 301 IU/L were noted. A muscle biopsy of the right bicep showed polymyositis. Computed tomography showed a right renal mass, and an analysis after right nephrectomy identified clear cell carcinoma. The muscle weakness subsided one month after nephrectomy and intravenous immunoglobulin therapy. Therefore, we suspect that the development of polymyositis in this patient was closely related to renal cell carcinoma.
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spelling pubmed-86662062021-12-28 Paraneoplastic Polymyositis Due to Renal Cell Carcinoma in a Patient with Autosomal Dominant Polycystic Kidney Disease Noda-Narita, Shoko Kanzaki, Mami Uesaka, Yoshikazu Suwabe, Tatsuya Kinowaki, Keiichi Marui, Yuhji Hoshino, Junichi Sawa, Naoki Ubara, Yoshifumi Intern Med Case Report We herein report a 70-year-old man with malaise and muscle weakness that had developed within a month. The patient also had abdominal fullness due to polycystic kidney disease. Severe proximal skeletal muscle weakness and mild elevation of creatinine kinase to 301 IU/L were noted. A muscle biopsy of the right bicep showed polymyositis. Computed tomography showed a right renal mass, and an analysis after right nephrectomy identified clear cell carcinoma. The muscle weakness subsided one month after nephrectomy and intravenous immunoglobulin therapy. Therefore, we suspect that the development of polymyositis in this patient was closely related to renal cell carcinoma. The Japanese Society of Internal Medicine 2021-05-29 2021-11-15 /pmc/articles/PMC8666206/ /pubmed/34053989 http://dx.doi.org/10.2169/internalmedicine.7417-21 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Noda-Narita, Shoko
Kanzaki, Mami
Uesaka, Yoshikazu
Suwabe, Tatsuya
Kinowaki, Keiichi
Marui, Yuhji
Hoshino, Junichi
Sawa, Naoki
Ubara, Yoshifumi
Paraneoplastic Polymyositis Due to Renal Cell Carcinoma in a Patient with Autosomal Dominant Polycystic Kidney Disease
title Paraneoplastic Polymyositis Due to Renal Cell Carcinoma in a Patient with Autosomal Dominant Polycystic Kidney Disease
title_full Paraneoplastic Polymyositis Due to Renal Cell Carcinoma in a Patient with Autosomal Dominant Polycystic Kidney Disease
title_fullStr Paraneoplastic Polymyositis Due to Renal Cell Carcinoma in a Patient with Autosomal Dominant Polycystic Kidney Disease
title_full_unstemmed Paraneoplastic Polymyositis Due to Renal Cell Carcinoma in a Patient with Autosomal Dominant Polycystic Kidney Disease
title_short Paraneoplastic Polymyositis Due to Renal Cell Carcinoma in a Patient with Autosomal Dominant Polycystic Kidney Disease
title_sort paraneoplastic polymyositis due to renal cell carcinoma in a patient with autosomal dominant polycystic kidney disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666206/
https://www.ncbi.nlm.nih.gov/pubmed/34053989
http://dx.doi.org/10.2169/internalmedicine.7417-21
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