Acute Megakaryoblastic Leukemia Harboring a Subclone Expressing BCR-ABL1 Fusion Gene Product

Acute myeloid leukemia (AML) with BCR-ABL1, also termed Philadelphia chromosome-positive AML (Ph+ AML), is a rare leukemia subtype classified by the World Health Organization in 2016. The characteristics of Ph+ AML have not been fully identified yet. We herein report a patient with Ph+ AML who pheno...

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Autores principales: Kashima, Emiko, Nakano, Eri, Watanabe, Yasuyuki, Imai, Hiroshi, Oka, Koji, Kageyama, Shinichi, Tanaka, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666224/
https://www.ncbi.nlm.nih.gov/pubmed/34053988
http://dx.doi.org/10.2169/internalmedicine.7335-21
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author Kashima, Emiko
Nakano, Eri
Watanabe, Yasuyuki
Imai, Hiroshi
Oka, Koji
Kageyama, Shinichi
Tanaka, Isao
author_facet Kashima, Emiko
Nakano, Eri
Watanabe, Yasuyuki
Imai, Hiroshi
Oka, Koji
Kageyama, Shinichi
Tanaka, Isao
author_sort Kashima, Emiko
collection PubMed
description Acute myeloid leukemia (AML) with BCR-ABL1, also termed Philadelphia chromosome-positive AML (Ph+ AML), is a rare leukemia subtype classified by the World Health Organization in 2016. The characteristics of Ph+ AML have not been fully identified yet. We herein report a patient with Ph+ AML who phenotypically exhibited megakaryoblastic characteristics, FAB:M7 and harbored a subclone expressing BCR-ABL1 gene fusion products. This case suggests that BCR-ABL1 was acquired as a subclone due to a secondary event that might have occurred late during leukemia evolution. Our findings may aid in deciphering the mechanism underlying Ph+ AML development in future studies.
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spelling pubmed-86662242021-12-28 Acute Megakaryoblastic Leukemia Harboring a Subclone Expressing BCR-ABL1 Fusion Gene Product Kashima, Emiko Nakano, Eri Watanabe, Yasuyuki Imai, Hiroshi Oka, Koji Kageyama, Shinichi Tanaka, Isao Intern Med Case Report Acute myeloid leukemia (AML) with BCR-ABL1, also termed Philadelphia chromosome-positive AML (Ph+ AML), is a rare leukemia subtype classified by the World Health Organization in 2016. The characteristics of Ph+ AML have not been fully identified yet. We herein report a patient with Ph+ AML who phenotypically exhibited megakaryoblastic characteristics, FAB:M7 and harbored a subclone expressing BCR-ABL1 gene fusion products. This case suggests that BCR-ABL1 was acquired as a subclone due to a secondary event that might have occurred late during leukemia evolution. Our findings may aid in deciphering the mechanism underlying Ph+ AML development in future studies. The Japanese Society of Internal Medicine 2021-05-29 2021-11-15 /pmc/articles/PMC8666224/ /pubmed/34053988 http://dx.doi.org/10.2169/internalmedicine.7335-21 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kashima, Emiko
Nakano, Eri
Watanabe, Yasuyuki
Imai, Hiroshi
Oka, Koji
Kageyama, Shinichi
Tanaka, Isao
Acute Megakaryoblastic Leukemia Harboring a Subclone Expressing BCR-ABL1 Fusion Gene Product
title Acute Megakaryoblastic Leukemia Harboring a Subclone Expressing BCR-ABL1 Fusion Gene Product
title_full Acute Megakaryoblastic Leukemia Harboring a Subclone Expressing BCR-ABL1 Fusion Gene Product
title_fullStr Acute Megakaryoblastic Leukemia Harboring a Subclone Expressing BCR-ABL1 Fusion Gene Product
title_full_unstemmed Acute Megakaryoblastic Leukemia Harboring a Subclone Expressing BCR-ABL1 Fusion Gene Product
title_short Acute Megakaryoblastic Leukemia Harboring a Subclone Expressing BCR-ABL1 Fusion Gene Product
title_sort acute megakaryoblastic leukemia harboring a subclone expressing bcr-abl1 fusion gene product
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666224/
https://www.ncbi.nlm.nih.gov/pubmed/34053988
http://dx.doi.org/10.2169/internalmedicine.7335-21
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