Cargando…

Eosinophilic Granulomatosis with Polyangiitis Presenting with Central Retinal Artery Occlusion During Treatment with Anti-interleukin-5 Receptor Monoclonal Antibody

Eosinophilic granulomatosis with polyangiitis (EGPA) is an anti-neutrophilic cytoplasm antibody (ANCA)-associated vasculitis characterized by asthma and eosinophilia. Although EGPA involves multiple organs, ocular involvement is infrequent and often carries a poor visual prognosis. We herein report...

Descripción completa

Detalles Bibliográficos
Autores principales: Nishiyama, Hirono, Tajiri, Tomoko, Yamabe, Toru, Yasukawa, Tsutomu, Takeda, Norihisa, Fukumitsu, Kensuke, Fukuda, Satoshi, Kanemitsu, Yoshihiro, Uemura, Takehiro, Ohkubo, Hirotsugu, Takemura, Masaya, Maeno, Ken, Ito, Yutaka, Oguri, Tetsuya, Naniwa, Taio, Niimi, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666228/
https://www.ncbi.nlm.nih.gov/pubmed/34092731
http://dx.doi.org/10.2169/internalmedicine.7027-21
Descripción
Sumario:Eosinophilic granulomatosis with polyangiitis (EGPA) is an anti-neutrophilic cytoplasm antibody (ANCA)-associated vasculitis characterized by asthma and eosinophilia. Although EGPA involves multiple organs, ocular involvement is infrequent and often carries a poor visual prognosis. We herein report a rare case of EGPA presenting with central retinal artery occlusion (CRAO) in which visual loss developed during treatment with anti-interleukin (IL)-5 receptor monoclonal antibody, and improvement in visual outcomes was attained after treatment combining high-dose oral corticosteroids, cyclophosphamide and an anticoagulant. Physicians should consider CRAO as an ophthalmic manifestation of EGPA in patients with severe eosinophilic asthma.