Listeria monocytogenes Bacteremia During Isatuximab Therapy in a Patient with Multiple Myeloma

An elderly patient with multiple myeloma (MM) was being treated with several regimens and developed a severe drug eruption, necessitating the use of atovaquone instead of trimethoprim-sulfamethoxazole for pneumocystis pneumonia (PCP) prophylaxis. For progressive MM, treatment with isatuximab, an ant...

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Autores principales: Ueno, Toshiyuki, Ohta, Takanori, Imanaga, Hiroshi, Nakazawa, Megumi, Sato, Yoriko, Sugio, Yasuhiro, Uchida, Yujiro, Ohno, Yuju, Uehara, Yasufumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666232/
https://www.ncbi.nlm.nih.gov/pubmed/34024861
http://dx.doi.org/10.2169/internalmedicine.7509-21
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author Ueno, Toshiyuki
Ohta, Takanori
Imanaga, Hiroshi
Nakazawa, Megumi
Sato, Yoriko
Sugio, Yasuhiro
Uchida, Yujiro
Ohno, Yuju
Uehara, Yasufumi
author_facet Ueno, Toshiyuki
Ohta, Takanori
Imanaga, Hiroshi
Nakazawa, Megumi
Sato, Yoriko
Sugio, Yasuhiro
Uchida, Yujiro
Ohno, Yuju
Uehara, Yasufumi
author_sort Ueno, Toshiyuki
collection PubMed
description An elderly patient with multiple myeloma (MM) was being treated with several regimens and developed a severe drug eruption, necessitating the use of atovaquone instead of trimethoprim-sulfamethoxazole for pneumocystis pneumonia (PCP) prophylaxis. For progressive MM, treatment with isatuximab, an anti-CD38 monoclonal antibody, was started. During the treatment, he developed Listeria monocytogenes bacteremia and recovered quickly with ampicillin administration. CD38 is closely related to the innate immune response against L. monocytogenes, and isatuximab may increase the risk of infection. Therefore, trimethoprim-sulfamethoxazole may be useful in the prevention of not only PCP but also L. monocytogenes infection.
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spelling pubmed-86662322021-12-28 Listeria monocytogenes Bacteremia During Isatuximab Therapy in a Patient with Multiple Myeloma Ueno, Toshiyuki Ohta, Takanori Imanaga, Hiroshi Nakazawa, Megumi Sato, Yoriko Sugio, Yasuhiro Uchida, Yujiro Ohno, Yuju Uehara, Yasufumi Intern Med Case Report An elderly patient with multiple myeloma (MM) was being treated with several regimens and developed a severe drug eruption, necessitating the use of atovaquone instead of trimethoprim-sulfamethoxazole for pneumocystis pneumonia (PCP) prophylaxis. For progressive MM, treatment with isatuximab, an anti-CD38 monoclonal antibody, was started. During the treatment, he developed Listeria monocytogenes bacteremia and recovered quickly with ampicillin administration. CD38 is closely related to the innate immune response against L. monocytogenes, and isatuximab may increase the risk of infection. Therefore, trimethoprim-sulfamethoxazole may be useful in the prevention of not only PCP but also L. monocytogenes infection. The Japanese Society of Internal Medicine 2021-05-22 2021-11-15 /pmc/articles/PMC8666232/ /pubmed/34024861 http://dx.doi.org/10.2169/internalmedicine.7509-21 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ueno, Toshiyuki
Ohta, Takanori
Imanaga, Hiroshi
Nakazawa, Megumi
Sato, Yoriko
Sugio, Yasuhiro
Uchida, Yujiro
Ohno, Yuju
Uehara, Yasufumi
Listeria monocytogenes Bacteremia During Isatuximab Therapy in a Patient with Multiple Myeloma
title Listeria monocytogenes Bacteremia During Isatuximab Therapy in a Patient with Multiple Myeloma
title_full Listeria monocytogenes Bacteremia During Isatuximab Therapy in a Patient with Multiple Myeloma
title_fullStr Listeria monocytogenes Bacteremia During Isatuximab Therapy in a Patient with Multiple Myeloma
title_full_unstemmed Listeria monocytogenes Bacteremia During Isatuximab Therapy in a Patient with Multiple Myeloma
title_short Listeria monocytogenes Bacteremia During Isatuximab Therapy in a Patient with Multiple Myeloma
title_sort listeria monocytogenes bacteremia during isatuximab therapy in a patient with multiple myeloma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666232/
https://www.ncbi.nlm.nih.gov/pubmed/34024861
http://dx.doi.org/10.2169/internalmedicine.7509-21
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