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Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension (CHESS1802): An International Multicenter Study

BACKGROUND AND AIMS: This study aimed to determine the performance of the non-invasive score using noncontrast-enhanced MRI (CHESS-DIS score) for detecting portal hypertension in cirrhosis. METHODS: In this international multicenter, diagnostic study (ClinicalTrials.gov, NCT03766880), patients with...

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Autores principales: Liu, Yanna, Tang, Tianyu, Örmeci, Necati, Huang, Yifei, Wang, Jitao, Li, Xiaoguo, Li, Zhiwei, An, Weimin, Liu, Dengxiang, Zhang, Chunqing, Liu, Changchun, Liu, Jinqiang, Liu, Chuan, Wang, Guangchuan, Mosconi, Cristina, Cappelli, Alberta, Bruno, Antonio, Akçalar, Seray, Çelebioğlu, Emrecan, Üstüner, Evren, Bilgiç, Sadık, Ellik, Zeynep, Asiller, Özgün Ömer, Li, Lei, Zhang, Haijun, Kang, Ning, Xu, Dan, He, Ruiling, Wang, Yan, Bu, Yang, Gu, Ye, Ju, Shenghong, Golfieri, Rita, Qi, Xiaolong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: XIA & HE Publishing Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666380/
https://www.ncbi.nlm.nih.gov/pubmed/34966645
http://dx.doi.org/10.14218/JCTH.2021.00177
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author Liu, Yanna
Tang, Tianyu
Örmeci, Necati
Huang, Yifei
Wang, Jitao
Li, Xiaoguo
Li, Zhiwei
An, Weimin
Liu, Dengxiang
Zhang, Chunqing
Liu, Changchun
Liu, Jinqiang
Liu, Chuan
Wang, Guangchuan
Mosconi, Cristina
Cappelli, Alberta
Bruno, Antonio
Akçalar, Seray
Çelebioğlu, Emrecan
Üstüner, Evren
Bilgiç, Sadık
Ellik, Zeynep
Asiller, Özgün Ömer
Li, Lei
Zhang, Haijun
Kang, Ning
Xu, Dan
He, Ruiling
Wang, Yan
Bu, Yang
Gu, Ye
Ju, Shenghong
Golfieri, Rita
Qi, Xiaolong
author_facet Liu, Yanna
Tang, Tianyu
Örmeci, Necati
Huang, Yifei
Wang, Jitao
Li, Xiaoguo
Li, Zhiwei
An, Weimin
Liu, Dengxiang
Zhang, Chunqing
Liu, Changchun
Liu, Jinqiang
Liu, Chuan
Wang, Guangchuan
Mosconi, Cristina
Cappelli, Alberta
Bruno, Antonio
Akçalar, Seray
Çelebioğlu, Emrecan
Üstüner, Evren
Bilgiç, Sadık
Ellik, Zeynep
Asiller, Özgün Ömer
Li, Lei
Zhang, Haijun
Kang, Ning
Xu, Dan
He, Ruiling
Wang, Yan
Bu, Yang
Gu, Ye
Ju, Shenghong
Golfieri, Rita
Qi, Xiaolong
author_sort Liu, Yanna
collection PubMed
description BACKGROUND AND AIMS: This study aimed to determine the performance of the non-invasive score using noncontrast-enhanced MRI (CHESS-DIS score) for detecting portal hypertension in cirrhosis. METHODS: In this international multicenter, diagnostic study (ClinicalTrials.gov, NCT03766880), patients with cirrhosis who had hepatic venous pressure gradient (HVPG) measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China (n=4) and Turkey (n=1) between December 2018 and April 2019. A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017. After segmentation of the liver on fat-suppressed T1-weighted MRI maps, CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity. RESULTS: A total of 149 patients were included, of which 124 were from four Chinese hospitals (training cohort) and 25 were from two international hospitals (validation cohort). A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36 (p<0.0001) and 0.55 (p<0.01) for the training and validation cohorts, respectively. The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension (CSPH) was 0.81 and 0.9 in the training and validation cohorts, respectively. The intraclass correlation coefficients for assessing the inter- and intra-observer agreement were 0.846 and 0.841, respectively. CONCLUSIONS: A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG. Besides, this score could be used to detect CSPH in patients with cirrhosis.
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spelling pubmed-86663802021-12-28 Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension (CHESS1802): An International Multicenter Study Liu, Yanna Tang, Tianyu Örmeci, Necati Huang, Yifei Wang, Jitao Li, Xiaoguo Li, Zhiwei An, Weimin Liu, Dengxiang Zhang, Chunqing Liu, Changchun Liu, Jinqiang Liu, Chuan Wang, Guangchuan Mosconi, Cristina Cappelli, Alberta Bruno, Antonio Akçalar, Seray Çelebioğlu, Emrecan Üstüner, Evren Bilgiç, Sadık Ellik, Zeynep Asiller, Özgün Ömer Li, Lei Zhang, Haijun Kang, Ning Xu, Dan He, Ruiling Wang, Yan Bu, Yang Gu, Ye Ju, Shenghong Golfieri, Rita Qi, Xiaolong J Clin Transl Hepatol Original Article BACKGROUND AND AIMS: This study aimed to determine the performance of the non-invasive score using noncontrast-enhanced MRI (CHESS-DIS score) for detecting portal hypertension in cirrhosis. METHODS: In this international multicenter, diagnostic study (ClinicalTrials.gov, NCT03766880), patients with cirrhosis who had hepatic venous pressure gradient (HVPG) measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China (n=4) and Turkey (n=1) between December 2018 and April 2019. A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017. After segmentation of the liver on fat-suppressed T1-weighted MRI maps, CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity. RESULTS: A total of 149 patients were included, of which 124 were from four Chinese hospitals (training cohort) and 25 were from two international hospitals (validation cohort). A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36 (p<0.0001) and 0.55 (p<0.01) for the training and validation cohorts, respectively. The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension (CSPH) was 0.81 and 0.9 in the training and validation cohorts, respectively. The intraclass correlation coefficients for assessing the inter- and intra-observer agreement were 0.846 and 0.841, respectively. CONCLUSIONS: A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG. Besides, this score could be used to detect CSPH in patients with cirrhosis. XIA & HE Publishing Inc. 2021-12-28 2021-09-30 /pmc/articles/PMC8666380/ /pubmed/34966645 http://dx.doi.org/10.14218/JCTH.2021.00177 Text en © 2021 Authors. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Liu, Yanna
Tang, Tianyu
Örmeci, Necati
Huang, Yifei
Wang, Jitao
Li, Xiaoguo
Li, Zhiwei
An, Weimin
Liu, Dengxiang
Zhang, Chunqing
Liu, Changchun
Liu, Jinqiang
Liu, Chuan
Wang, Guangchuan
Mosconi, Cristina
Cappelli, Alberta
Bruno, Antonio
Akçalar, Seray
Çelebioğlu, Emrecan
Üstüner, Evren
Bilgiç, Sadık
Ellik, Zeynep
Asiller, Özgün Ömer
Li, Lei
Zhang, Haijun
Kang, Ning
Xu, Dan
He, Ruiling
Wang, Yan
Bu, Yang
Gu, Ye
Ju, Shenghong
Golfieri, Rita
Qi, Xiaolong
Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension (CHESS1802): An International Multicenter Study
title Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension (CHESS1802): An International Multicenter Study
title_full Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension (CHESS1802): An International Multicenter Study
title_fullStr Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension (CHESS1802): An International Multicenter Study
title_full_unstemmed Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension (CHESS1802): An International Multicenter Study
title_short Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension (CHESS1802): An International Multicenter Study
title_sort noncontrast-enhanced mri-based noninvasive score for portal hypertension (chess1802): an international multicenter study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666380/
https://www.ncbi.nlm.nih.gov/pubmed/34966645
http://dx.doi.org/10.14218/JCTH.2021.00177
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