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Altered Cortico-Subcortical Network After Adolescent Alcohol Exposure Mediates Behavioral Deficits in Flexible Decision-Making

Behavioral flexibility, the ability to modify behavior according to changing conditions, is essential to optimize decision-making. Deficits in behavioral flexibility that persist into adulthood are one consequence of adolescent alcohol exposure, and another is decreased functional connectivity in br...

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Autores principales: Gómez-A, Alexander, Dannenhoffer, Carol A., Elton, Amanda, Lee, Sung-Ho, Ban, Woomi, Shih, Yen-Yu Ian, Boettiger, Charlotte A., Robinson, Donita L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666507/
https://www.ncbi.nlm.nih.gov/pubmed/34912227
http://dx.doi.org/10.3389/fphar.2021.778884
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author Gómez-A, Alexander
Dannenhoffer, Carol A.
Elton, Amanda
Lee, Sung-Ho
Ban, Woomi
Shih, Yen-Yu Ian
Boettiger, Charlotte A.
Robinson, Donita L.
author_facet Gómez-A, Alexander
Dannenhoffer, Carol A.
Elton, Amanda
Lee, Sung-Ho
Ban, Woomi
Shih, Yen-Yu Ian
Boettiger, Charlotte A.
Robinson, Donita L.
author_sort Gómez-A, Alexander
collection PubMed
description Behavioral flexibility, the ability to modify behavior according to changing conditions, is essential to optimize decision-making. Deficits in behavioral flexibility that persist into adulthood are one consequence of adolescent alcohol exposure, and another is decreased functional connectivity in brain structures involved in decision-making; however, a link between these two outcomes has not been established. We assessed effects of adolescent alcohol and sex on both Pavlovian and instrumental behaviors and resting-state functional connectivity MRI in adult animals to determine associations between behavioral flexibility and resting-state functional connectivity. Alcohol exposure impaired attentional set reversals and decreased functional connectivity among cortical and subcortical regions-of-interest that underlie flexible behavior. Moreover, mediation analyses indicated that adolescent alcohol-induced reductions in functional connectivity within a subnetwork of affected brain regions statistically mediated errors committed during reversal learning. These results provide a novel link between persistent reductions in brain functional connectivity and deficits in behavioral flexibility resulting from adolescent alcohol exposure.
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spelling pubmed-86665072021-12-14 Altered Cortico-Subcortical Network After Adolescent Alcohol Exposure Mediates Behavioral Deficits in Flexible Decision-Making Gómez-A, Alexander Dannenhoffer, Carol A. Elton, Amanda Lee, Sung-Ho Ban, Woomi Shih, Yen-Yu Ian Boettiger, Charlotte A. Robinson, Donita L. Front Pharmacol Pharmacology Behavioral flexibility, the ability to modify behavior according to changing conditions, is essential to optimize decision-making. Deficits in behavioral flexibility that persist into adulthood are one consequence of adolescent alcohol exposure, and another is decreased functional connectivity in brain structures involved in decision-making; however, a link between these two outcomes has not been established. We assessed effects of adolescent alcohol and sex on both Pavlovian and instrumental behaviors and resting-state functional connectivity MRI in adult animals to determine associations between behavioral flexibility and resting-state functional connectivity. Alcohol exposure impaired attentional set reversals and decreased functional connectivity among cortical and subcortical regions-of-interest that underlie flexible behavior. Moreover, mediation analyses indicated that adolescent alcohol-induced reductions in functional connectivity within a subnetwork of affected brain regions statistically mediated errors committed during reversal learning. These results provide a novel link between persistent reductions in brain functional connectivity and deficits in behavioral flexibility resulting from adolescent alcohol exposure. Frontiers Media S.A. 2021-11-29 /pmc/articles/PMC8666507/ /pubmed/34912227 http://dx.doi.org/10.3389/fphar.2021.778884 Text en Copyright © 2021 Gómez-A, Dannenhoffer, Elton, Lee, Ban, Shih, Boettiger and Robinson. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Gómez-A, Alexander
Dannenhoffer, Carol A.
Elton, Amanda
Lee, Sung-Ho
Ban, Woomi
Shih, Yen-Yu Ian
Boettiger, Charlotte A.
Robinson, Donita L.
Altered Cortico-Subcortical Network After Adolescent Alcohol Exposure Mediates Behavioral Deficits in Flexible Decision-Making
title Altered Cortico-Subcortical Network After Adolescent Alcohol Exposure Mediates Behavioral Deficits in Flexible Decision-Making
title_full Altered Cortico-Subcortical Network After Adolescent Alcohol Exposure Mediates Behavioral Deficits in Flexible Decision-Making
title_fullStr Altered Cortico-Subcortical Network After Adolescent Alcohol Exposure Mediates Behavioral Deficits in Flexible Decision-Making
title_full_unstemmed Altered Cortico-Subcortical Network After Adolescent Alcohol Exposure Mediates Behavioral Deficits in Flexible Decision-Making
title_short Altered Cortico-Subcortical Network After Adolescent Alcohol Exposure Mediates Behavioral Deficits in Flexible Decision-Making
title_sort altered cortico-subcortical network after adolescent alcohol exposure mediates behavioral deficits in flexible decision-making
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666507/
https://www.ncbi.nlm.nih.gov/pubmed/34912227
http://dx.doi.org/10.3389/fphar.2021.778884
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