A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer

AFAP1-AS1 is a long non-coding RNA which partakes in the pathoetiology of several cancers. The sense protein coding gene from this locus partakes in the regulation of cytophagy, cell motility, invasive characteristics of cells and metastatic ability. In addition to acting in concert with AFAP1, AFAP...

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Autores principales: Ghafouri-Fard, Soudeh, Khoshbakht, Tayybeh, Hussen, Bashdar Mahmud, Taheri, Mohammad, Mokhtari, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666534/
https://www.ncbi.nlm.nih.gov/pubmed/34912717
http://dx.doi.org/10.3389/fonc.2021.777849
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author Ghafouri-Fard, Soudeh
Khoshbakht, Tayybeh
Hussen, Bashdar Mahmud
Taheri, Mohammad
Mokhtari, Majid
author_facet Ghafouri-Fard, Soudeh
Khoshbakht, Tayybeh
Hussen, Bashdar Mahmud
Taheri, Mohammad
Mokhtari, Majid
author_sort Ghafouri-Fard, Soudeh
collection PubMed
description AFAP1-AS1 is a long non-coding RNA which partakes in the pathoetiology of several cancers. The sense protein coding gene from this locus partakes in the regulation of cytophagy, cell motility, invasive characteristics of cells and metastatic ability. In addition to acting in concert with AFAP1, AFAP1-AS1 can sequester a number of cancer-related miRNAs, thus affecting activity of signaling pathways involved in cancer progression. Most of animal studies have confirmed that AFAP1-AS1 silencing can reduce tumor volume and invasive behavior of tumor cells in the xenograft models. Moreover, statistical analyses in the human subjects have shown strong correlation between expression levels of this lncRNA and clinical outcomes. In the present work, we review the impact of AFAP1-AS1 in the carcinogenesis.
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spelling pubmed-86665342021-12-14 A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer Ghafouri-Fard, Soudeh Khoshbakht, Tayybeh Hussen, Bashdar Mahmud Taheri, Mohammad Mokhtari, Majid Front Oncol Oncology AFAP1-AS1 is a long non-coding RNA which partakes in the pathoetiology of several cancers. The sense protein coding gene from this locus partakes in the regulation of cytophagy, cell motility, invasive characteristics of cells and metastatic ability. In addition to acting in concert with AFAP1, AFAP1-AS1 can sequester a number of cancer-related miRNAs, thus affecting activity of signaling pathways involved in cancer progression. Most of animal studies have confirmed that AFAP1-AS1 silencing can reduce tumor volume and invasive behavior of tumor cells in the xenograft models. Moreover, statistical analyses in the human subjects have shown strong correlation between expression levels of this lncRNA and clinical outcomes. In the present work, we review the impact of AFAP1-AS1 in the carcinogenesis. Frontiers Media S.A. 2021-11-29 /pmc/articles/PMC8666534/ /pubmed/34912717 http://dx.doi.org/10.3389/fonc.2021.777849 Text en Copyright © 2021 Ghafouri-Fard, Khoshbakht, Hussen, Taheri and Mokhtari https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ghafouri-Fard, Soudeh
Khoshbakht, Tayybeh
Hussen, Bashdar Mahmud
Taheri, Mohammad
Mokhtari, Majid
A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer
title A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer
title_full A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer
title_fullStr A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer
title_full_unstemmed A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer
title_short A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer
title_sort review on the role of afap1-as1 in the pathoetiology of cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666534/
https://www.ncbi.nlm.nih.gov/pubmed/34912717
http://dx.doi.org/10.3389/fonc.2021.777849
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