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Metachronous Bilateral Testicular Plasmacytoma After an Initial Soft Tissue, Extramedullary Plasmacytoma

Testicular plasmacytoma is a rare extramedullary manifestation of plasma cell dyscrasia. We report a case of a 53-year-old man who presented with a metachronous testicular lesion originating from a soft tissue plasmacytoma of the oral cavity. He underwent radical orchiectomy and a year later, presen...

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Autores principales: Manolitsis, Ioannis, Tzelves, Lazaros, Koutoulidis, Vassilis, Gavriatopoulou, Maria, Varkarakis, Ioannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666563/
https://www.ncbi.nlm.nih.gov/pubmed/34934542
http://dx.doi.org/10.7759/cureus.19517
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author Manolitsis, Ioannis
Tzelves, Lazaros
Koutoulidis, Vassilis
Gavriatopoulou, Maria
Varkarakis, Ioannis
author_facet Manolitsis, Ioannis
Tzelves, Lazaros
Koutoulidis, Vassilis
Gavriatopoulou, Maria
Varkarakis, Ioannis
author_sort Manolitsis, Ioannis
collection PubMed
description Testicular plasmacytoma is a rare extramedullary manifestation of plasma cell dyscrasia. We report a case of a 53-year-old man who presented with a metachronous testicular lesion originating from a soft tissue plasmacytoma of the oral cavity. He underwent radical orchiectomy and a year later, presented with testicular plasmacytoma in the contralateral testis. He received induction chemotherapy, autologous stem cell transplantation with high dose melphalan and maintenance with lenalidomide, as he refused orchiectomy and achieved complete remission. However, six months post-transplant, he relapsed with localized disease in his testis, received second-line chemotherapy, after refusing orchiectomy and still remains in partial remission and alive.
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spelling pubmed-86665632021-12-20 Metachronous Bilateral Testicular Plasmacytoma After an Initial Soft Tissue, Extramedullary Plasmacytoma Manolitsis, Ioannis Tzelves, Lazaros Koutoulidis, Vassilis Gavriatopoulou, Maria Varkarakis, Ioannis Cureus Urology Testicular plasmacytoma is a rare extramedullary manifestation of plasma cell dyscrasia. We report a case of a 53-year-old man who presented with a metachronous testicular lesion originating from a soft tissue plasmacytoma of the oral cavity. He underwent radical orchiectomy and a year later, presented with testicular plasmacytoma in the contralateral testis. He received induction chemotherapy, autologous stem cell transplantation with high dose melphalan and maintenance with lenalidomide, as he refused orchiectomy and achieved complete remission. However, six months post-transplant, he relapsed with localized disease in his testis, received second-line chemotherapy, after refusing orchiectomy and still remains in partial remission and alive. Cureus 2021-11-12 /pmc/articles/PMC8666563/ /pubmed/34934542 http://dx.doi.org/10.7759/cureus.19517 Text en Copyright © 2021, Manolitsis et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Urology
Manolitsis, Ioannis
Tzelves, Lazaros
Koutoulidis, Vassilis
Gavriatopoulou, Maria
Varkarakis, Ioannis
Metachronous Bilateral Testicular Plasmacytoma After an Initial Soft Tissue, Extramedullary Plasmacytoma
title Metachronous Bilateral Testicular Plasmacytoma After an Initial Soft Tissue, Extramedullary Plasmacytoma
title_full Metachronous Bilateral Testicular Plasmacytoma After an Initial Soft Tissue, Extramedullary Plasmacytoma
title_fullStr Metachronous Bilateral Testicular Plasmacytoma After an Initial Soft Tissue, Extramedullary Plasmacytoma
title_full_unstemmed Metachronous Bilateral Testicular Plasmacytoma After an Initial Soft Tissue, Extramedullary Plasmacytoma
title_short Metachronous Bilateral Testicular Plasmacytoma After an Initial Soft Tissue, Extramedullary Plasmacytoma
title_sort metachronous bilateral testicular plasmacytoma after an initial soft tissue, extramedullary plasmacytoma
topic Urology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666563/
https://www.ncbi.nlm.nih.gov/pubmed/34934542
http://dx.doi.org/10.7759/cureus.19517
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