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Metachronous Bilateral Testicular Plasmacytoma After an Initial Soft Tissue, Extramedullary Plasmacytoma
Testicular plasmacytoma is a rare extramedullary manifestation of plasma cell dyscrasia. We report a case of a 53-year-old man who presented with a metachronous testicular lesion originating from a soft tissue plasmacytoma of the oral cavity. He underwent radical orchiectomy and a year later, presen...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666563/ https://www.ncbi.nlm.nih.gov/pubmed/34934542 http://dx.doi.org/10.7759/cureus.19517 |
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author | Manolitsis, Ioannis Tzelves, Lazaros Koutoulidis, Vassilis Gavriatopoulou, Maria Varkarakis, Ioannis |
author_facet | Manolitsis, Ioannis Tzelves, Lazaros Koutoulidis, Vassilis Gavriatopoulou, Maria Varkarakis, Ioannis |
author_sort | Manolitsis, Ioannis |
collection | PubMed |
description | Testicular plasmacytoma is a rare extramedullary manifestation of plasma cell dyscrasia. We report a case of a 53-year-old man who presented with a metachronous testicular lesion originating from a soft tissue plasmacytoma of the oral cavity. He underwent radical orchiectomy and a year later, presented with testicular plasmacytoma in the contralateral testis. He received induction chemotherapy, autologous stem cell transplantation with high dose melphalan and maintenance with lenalidomide, as he refused orchiectomy and achieved complete remission. However, six months post-transplant, he relapsed with localized disease in his testis, received second-line chemotherapy, after refusing orchiectomy and still remains in partial remission and alive. |
format | Online Article Text |
id | pubmed-8666563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-86665632021-12-20 Metachronous Bilateral Testicular Plasmacytoma After an Initial Soft Tissue, Extramedullary Plasmacytoma Manolitsis, Ioannis Tzelves, Lazaros Koutoulidis, Vassilis Gavriatopoulou, Maria Varkarakis, Ioannis Cureus Urology Testicular plasmacytoma is a rare extramedullary manifestation of plasma cell dyscrasia. We report a case of a 53-year-old man who presented with a metachronous testicular lesion originating from a soft tissue plasmacytoma of the oral cavity. He underwent radical orchiectomy and a year later, presented with testicular plasmacytoma in the contralateral testis. He received induction chemotherapy, autologous stem cell transplantation with high dose melphalan and maintenance with lenalidomide, as he refused orchiectomy and achieved complete remission. However, six months post-transplant, he relapsed with localized disease in his testis, received second-line chemotherapy, after refusing orchiectomy and still remains in partial remission and alive. Cureus 2021-11-12 /pmc/articles/PMC8666563/ /pubmed/34934542 http://dx.doi.org/10.7759/cureus.19517 Text en Copyright © 2021, Manolitsis et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Urology Manolitsis, Ioannis Tzelves, Lazaros Koutoulidis, Vassilis Gavriatopoulou, Maria Varkarakis, Ioannis Metachronous Bilateral Testicular Plasmacytoma After an Initial Soft Tissue, Extramedullary Plasmacytoma |
title | Metachronous Bilateral Testicular Plasmacytoma After an Initial Soft Tissue, Extramedullary Plasmacytoma |
title_full | Metachronous Bilateral Testicular Plasmacytoma After an Initial Soft Tissue, Extramedullary Plasmacytoma |
title_fullStr | Metachronous Bilateral Testicular Plasmacytoma After an Initial Soft Tissue, Extramedullary Plasmacytoma |
title_full_unstemmed | Metachronous Bilateral Testicular Plasmacytoma After an Initial Soft Tissue, Extramedullary Plasmacytoma |
title_short | Metachronous Bilateral Testicular Plasmacytoma After an Initial Soft Tissue, Extramedullary Plasmacytoma |
title_sort | metachronous bilateral testicular plasmacytoma after an initial soft tissue, extramedullary plasmacytoma |
topic | Urology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666563/ https://www.ncbi.nlm.nih.gov/pubmed/34934542 http://dx.doi.org/10.7759/cureus.19517 |
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