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Drug Transporters in the Kidney: Perspectives on Species Differences, Disease Status, and Molecular Docking
The kidneys are a pair of important organs that excretes endogenous waste and exogenous biological agents from the body. Numerous transporters are involved in the excretion process. The levels of these transporters could affect the pharmacokinetics of many drugs, such as organic anion drugs, organic...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666590/ https://www.ncbi.nlm.nih.gov/pubmed/34912216 http://dx.doi.org/10.3389/fphar.2021.746208 |
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author | Zou, Wei Shi, Birui Zeng, Ting Zhang, Yan Huang, Baolin Ouyang, Bo Cai, Zheng Liu, Menghua |
author_facet | Zou, Wei Shi, Birui Zeng, Ting Zhang, Yan Huang, Baolin Ouyang, Bo Cai, Zheng Liu, Menghua |
author_sort | Zou, Wei |
collection | PubMed |
description | The kidneys are a pair of important organs that excretes endogenous waste and exogenous biological agents from the body. Numerous transporters are involved in the excretion process. The levels of these transporters could affect the pharmacokinetics of many drugs, such as organic anion drugs, organic cationic drugs, and peptide drugs. Eleven drug transporters in the kidney (OAT1, OAT3, OATP4C1, OCT2, MDR1, BCRP, MATE1, MATE2-K, OAT4, MRP2, and MRP4) have become necessary research items in the development of innovative drugs. However, the levels of these transporters vary between different species, sex-genders, ages, and disease statuses, which may lead to different pharmacokinetics of drugs. Here, we review the differences of the important transports in the mentioned conditions, in order to help clinicians to improve clinical prescriptions for patients. To predict drug-drug interactions (DDIs) caused by renal drug transporters, the molecular docking method is used for rapid screening of substrates or inhibitors of the drug transporters. Here, we review a large number of natural products that represent potential substrates and/or inhibitors of transporters by the molecular docking method. |
format | Online Article Text |
id | pubmed-8666590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86665902021-12-14 Drug Transporters in the Kidney: Perspectives on Species Differences, Disease Status, and Molecular Docking Zou, Wei Shi, Birui Zeng, Ting Zhang, Yan Huang, Baolin Ouyang, Bo Cai, Zheng Liu, Menghua Front Pharmacol Pharmacology The kidneys are a pair of important organs that excretes endogenous waste and exogenous biological agents from the body. Numerous transporters are involved in the excretion process. The levels of these transporters could affect the pharmacokinetics of many drugs, such as organic anion drugs, organic cationic drugs, and peptide drugs. Eleven drug transporters in the kidney (OAT1, OAT3, OATP4C1, OCT2, MDR1, BCRP, MATE1, MATE2-K, OAT4, MRP2, and MRP4) have become necessary research items in the development of innovative drugs. However, the levels of these transporters vary between different species, sex-genders, ages, and disease statuses, which may lead to different pharmacokinetics of drugs. Here, we review the differences of the important transports in the mentioned conditions, in order to help clinicians to improve clinical prescriptions for patients. To predict drug-drug interactions (DDIs) caused by renal drug transporters, the molecular docking method is used for rapid screening of substrates or inhibitors of the drug transporters. Here, we review a large number of natural products that represent potential substrates and/or inhibitors of transporters by the molecular docking method. Frontiers Media S.A. 2021-11-29 /pmc/articles/PMC8666590/ /pubmed/34912216 http://dx.doi.org/10.3389/fphar.2021.746208 Text en Copyright © 2021 Zou, Shi, Zeng, Zhang, Huang, Ouyang, Cai and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Zou, Wei Shi, Birui Zeng, Ting Zhang, Yan Huang, Baolin Ouyang, Bo Cai, Zheng Liu, Menghua Drug Transporters in the Kidney: Perspectives on Species Differences, Disease Status, and Molecular Docking |
title | Drug Transporters in the Kidney: Perspectives on Species Differences, Disease Status, and Molecular Docking |
title_full | Drug Transporters in the Kidney: Perspectives on Species Differences, Disease Status, and Molecular Docking |
title_fullStr | Drug Transporters in the Kidney: Perspectives on Species Differences, Disease Status, and Molecular Docking |
title_full_unstemmed | Drug Transporters in the Kidney: Perspectives on Species Differences, Disease Status, and Molecular Docking |
title_short | Drug Transporters in the Kidney: Perspectives on Species Differences, Disease Status, and Molecular Docking |
title_sort | drug transporters in the kidney: perspectives on species differences, disease status, and molecular docking |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666590/ https://www.ncbi.nlm.nih.gov/pubmed/34912216 http://dx.doi.org/10.3389/fphar.2021.746208 |
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