Synthesis and Discovery of Schiff Base Bearing Furopyrimidinone for Selective Recognition of Zn(2+) and its Applications in Cell Imaging and Detection of Cu(2+)

A simplefuro [2,3-d]pyrimidinone-based Schiff base FPS was synthesized via aza-Wittig reaction and structure elucidation was carried out by spectroscopic studies FT-IR, 1H NMR, and 13C NMR and mass spectrometry. FPS showed weak fluorescence emission in methanol and the selectivity of FPS to different metal ions (Mn(2+), Ca(2+), Fe(2+), Fe(3+), Mg(2+), Al(3+), Ba(2+), Ag(+), Co(2+), Na(+), K(+), Cu(2+), Zn(2+), Pb(2+), Bi(3+)) were studied by absorption and fluorescence titration. The results show that FPS has selective fluorescence sensing behavior for Zn(2+) ions and the limit of detection (LOD) was calculated to be 1.19 × 10(–8) mol/L. Moreover, FPS-Zn(2+) acts as a metal based highly selective and sensitive new chemosensor for Cu(2+) ions and the LOD was calculated to be 2.25 × 10(–7) mol/L. In accordance with the results and theoretical calculations, we suspected that the binding mechanisms of FPS to Zn(2+) and Cu(2+) were assigned to be the cooperative interaction of Zn(2+)(Cu(2+))-N.