The sodium/glucose cotransporters as potential therapeutic targets for CF lung diseases revealed by human lung organoid swelling assay

Cystic fibrosis (CF) is a lethal autosomal-recessive inherited disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. In the present work, we derived human proximal lung organoids (HLOs) from patient-derived pluripotent stem cells (PSCs) carrying disease-...

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Detalles Bibliográficos
Autores principales: Hirai, Hiroyuki, Liang, Xiubin, Sun, Yifei, Zhang, Yihan, Zhang, Jifeng, Chen, Y. Eugene, Mou, Hongmei, Zhao, Youyang, Xu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666609/
https://www.ncbi.nlm.nih.gov/pubmed/34977268
http://dx.doi.org/10.1016/j.omtm.2021.11.008

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