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Sarcoidosis in Iceland: a nationwide study of epidemiology, clinical picture and environmental exposure

BACKGROUND: This nationwide study aimed to elucidate the incidence and clinical characteristics of tissue-verified sarcoidosis in Iceland. A secondary aim was to analyse sex differences and identify possible environmental factors contributing to the pathological process. MATERIALS AND METHODS: This...

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Autores principales: Haraldsdóttir, Sigríður Ólína, Jonasson, Jon Gunnlaugur, Jorundsdottir, Kristin Bara, Hannesson, Haraldur Jon, Gislason, Thorarinn, Gudbjornsson, Bjorn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666626/
https://www.ncbi.nlm.nih.gov/pubmed/34912885
http://dx.doi.org/10.1183/23120541.00550-2021
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author Haraldsdóttir, Sigríður Ólína
Jonasson, Jon Gunnlaugur
Jorundsdottir, Kristin Bara
Hannesson, Haraldur Jon
Gislason, Thorarinn
Gudbjornsson, Bjorn
author_facet Haraldsdóttir, Sigríður Ólína
Jonasson, Jon Gunnlaugur
Jorundsdottir, Kristin Bara
Hannesson, Haraldur Jon
Gislason, Thorarinn
Gudbjornsson, Bjorn
author_sort Haraldsdóttir, Sigríður Ólína
collection PubMed
description BACKGROUND: This nationwide study aimed to elucidate the incidence and clinical characteristics of tissue-verified sarcoidosis in Iceland. A secondary aim was to analyse sex differences and identify possible environmental factors contributing to the pathological process. MATERIALS AND METHODS: This is a descriptive study covering 36 years (January 1, 1981 through December 31, 2016). Histopathological reports and electronic hospital discharge registries were reviewed in context for granulomas and/or sarcoidosis. National data were used for comparison regarding smoking habits and occupation, adjusted for age, sex and year of diagnosis. The data were stored in FileMaker and calculations were made by extracting data from this database to the statistical software package R. RESULTS: A total of 418 patients (54% females) were diagnosed with tissue-verified sarcoidosis. The incidence rate was 4.15/100 000/year, similar among females and males. The mean age at diagnosis was higher among females (53.0±14.2 years) than males (48.2±13.8 years). Fatigue was the most frequent single symptom (49.7%), but when all respiratory symptoms were grouped, they were the most frequent symptoms (60%). No significant difference was found between smoking status and sarcoidosis. Possible hazardous exposure in the workplace was reported by 19.4% of the cases. CONCLUSION: The incidence of sarcoidosis in Iceland was higher than in an Asian population where the same inclusion criteria were applied. The clinical picture diverges partly from that in the Asian population but resembles that among other Caucasians. Fatigue and respiratory symptoms were predominant. The biphasic pattern of age at disease debut seen elsewhere among females was not evident in Iceland.
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spelling pubmed-86666262021-12-14 Sarcoidosis in Iceland: a nationwide study of epidemiology, clinical picture and environmental exposure Haraldsdóttir, Sigríður Ólína Jonasson, Jon Gunnlaugur Jorundsdottir, Kristin Bara Hannesson, Haraldur Jon Gislason, Thorarinn Gudbjornsson, Bjorn ERJ Open Res Original Research Articles BACKGROUND: This nationwide study aimed to elucidate the incidence and clinical characteristics of tissue-verified sarcoidosis in Iceland. A secondary aim was to analyse sex differences and identify possible environmental factors contributing to the pathological process. MATERIALS AND METHODS: This is a descriptive study covering 36 years (January 1, 1981 through December 31, 2016). Histopathological reports and electronic hospital discharge registries were reviewed in context for granulomas and/or sarcoidosis. National data were used for comparison regarding smoking habits and occupation, adjusted for age, sex and year of diagnosis. The data were stored in FileMaker and calculations were made by extracting data from this database to the statistical software package R. RESULTS: A total of 418 patients (54% females) were diagnosed with tissue-verified sarcoidosis. The incidence rate was 4.15/100 000/year, similar among females and males. The mean age at diagnosis was higher among females (53.0±14.2 years) than males (48.2±13.8 years). Fatigue was the most frequent single symptom (49.7%), but when all respiratory symptoms were grouped, they were the most frequent symptoms (60%). No significant difference was found between smoking status and sarcoidosis. Possible hazardous exposure in the workplace was reported by 19.4% of the cases. CONCLUSION: The incidence of sarcoidosis in Iceland was higher than in an Asian population where the same inclusion criteria were applied. The clinical picture diverges partly from that in the Asian population but resembles that among other Caucasians. Fatigue and respiratory symptoms were predominant. The biphasic pattern of age at disease debut seen elsewhere among females was not evident in Iceland. European Respiratory Society 2021-12-13 /pmc/articles/PMC8666626/ /pubmed/34912885 http://dx.doi.org/10.1183/23120541.00550-2021 Text en Copyright ©The authors 2021 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org)
spellingShingle Original Research Articles
Haraldsdóttir, Sigríður Ólína
Jonasson, Jon Gunnlaugur
Jorundsdottir, Kristin Bara
Hannesson, Haraldur Jon
Gislason, Thorarinn
Gudbjornsson, Bjorn
Sarcoidosis in Iceland: a nationwide study of epidemiology, clinical picture and environmental exposure
title Sarcoidosis in Iceland: a nationwide study of epidemiology, clinical picture and environmental exposure
title_full Sarcoidosis in Iceland: a nationwide study of epidemiology, clinical picture and environmental exposure
title_fullStr Sarcoidosis in Iceland: a nationwide study of epidemiology, clinical picture and environmental exposure
title_full_unstemmed Sarcoidosis in Iceland: a nationwide study of epidemiology, clinical picture and environmental exposure
title_short Sarcoidosis in Iceland: a nationwide study of epidemiology, clinical picture and environmental exposure
title_sort sarcoidosis in iceland: a nationwide study of epidemiology, clinical picture and environmental exposure
topic Original Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666626/
https://www.ncbi.nlm.nih.gov/pubmed/34912885
http://dx.doi.org/10.1183/23120541.00550-2021
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