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Smurf1 silencing restores PTEN expression that ameliorates progression of human glioblastoma and sensitizes tumor cells to mTORC1/C2 inhibitor Torin1

Amplification of ubiquitin E3 ligase Smurf1 promotes degradation of PTEN leading to hyperactivation of the Akt/mTORC1 pathway. However, inhibitors of this pathway have not hitherto yielded promising results in clinical studies because of strong drug resistance. Here, we investigated Smurf1 expressio...

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Detalles Bibliográficos
Autores principales:	Xia, Qin, Li, Wenxuan, Ali, Sakhawat, Xu, Mengchuan, Li, Yang, Li, Shengzhen, Meng, Xinyi, Liu, Liqun, Dong, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666673/ https://www.ncbi.nlm.nih.gov/pubmed/34917902 http://dx.doi.org/10.1016/j.isci.2021.103528

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