Cargando…

ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes

Autophagy is an evolutionarily conserved vacuolar process functioning in the degradation of cellular components for reuse. In plants, autophagy is generally activated upon stress and its regulation is executed by numbers of AuTophaGy-related genes (ATGs), of which the ATG8 plays a dual role in both...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Wanqing, Liu, Zinan, Mo, Zulong, Guo, Shaoying, Liu, Yunfeng, Xie, Qingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666691/
https://www.ncbi.nlm.nih.gov/pubmed/34912364
http://dx.doi.org/10.3389/fpls.2021.783881
_version_ 1784614265104105472
author Liu, Wanqing
Liu, Zinan
Mo, Zulong
Guo, Shaoying
Liu, Yunfeng
Xie, Qingjun
author_facet Liu, Wanqing
Liu, Zinan
Mo, Zulong
Guo, Shaoying
Liu, Yunfeng
Xie, Qingjun
author_sort Liu, Wanqing
collection PubMed
description Autophagy is an evolutionarily conserved vacuolar process functioning in the degradation of cellular components for reuse. In plants, autophagy is generally activated upon stress and its regulation is executed by numbers of AuTophaGy-related genes (ATGs), of which the ATG8 plays a dual role in both biogenesis of autophagosomes and recruitment of ATG8-interacting motif (AIM) anchored selective autophagy receptors (SARs). Such motif is either termed as AIM or ubiquitin-interacting motif (UIM), corresponding to the LC3-interacting region (LIR)/AIM docking site (LDS) or the UIM docking site (UDS) of ATG8, respectively. To date, dozens of AIM or UIM containing SARs have been characterized. However, the knowledge of these motifs is still obscured. In this review, we intend to summarize the current understanding of SAR proteins and discuss the conservation and diversification of the AIMs/UIMs, expectantly providing new insights into the evolution of them in various biological processes in plants.
format Online
Article
Text
id pubmed-8666691
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-86666912021-12-14 ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes Liu, Wanqing Liu, Zinan Mo, Zulong Guo, Shaoying Liu, Yunfeng Xie, Qingjun Front Plant Sci Plant Science Autophagy is an evolutionarily conserved vacuolar process functioning in the degradation of cellular components for reuse. In plants, autophagy is generally activated upon stress and its regulation is executed by numbers of AuTophaGy-related genes (ATGs), of which the ATG8 plays a dual role in both biogenesis of autophagosomes and recruitment of ATG8-interacting motif (AIM) anchored selective autophagy receptors (SARs). Such motif is either termed as AIM or ubiquitin-interacting motif (UIM), corresponding to the LC3-interacting region (LIR)/AIM docking site (LDS) or the UIM docking site (UDS) of ATG8, respectively. To date, dozens of AIM or UIM containing SARs have been characterized. However, the knowledge of these motifs is still obscured. In this review, we intend to summarize the current understanding of SAR proteins and discuss the conservation and diversification of the AIMs/UIMs, expectantly providing new insights into the evolution of them in various biological processes in plants. Frontiers Media S.A. 2021-11-29 /pmc/articles/PMC8666691/ /pubmed/34912364 http://dx.doi.org/10.3389/fpls.2021.783881 Text en Copyright © 2021 Liu, Liu, Mo, Guo, Liu and Xie. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Plant Science
Liu, Wanqing
Liu, Zinan
Mo, Zulong
Guo, Shaoying
Liu, Yunfeng
Xie, Qingjun
ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes
title ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes
title_full ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes
title_fullStr ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes
title_full_unstemmed ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes
title_short ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes
title_sort atg8-interacting motif: evolution and function in selective autophagy of targeting biological processes
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666691/
https://www.ncbi.nlm.nih.gov/pubmed/34912364
http://dx.doi.org/10.3389/fpls.2021.783881
work_keys_str_mv AT liuwanqing atg8interactingmotifevolutionandfunctioninselectiveautophagyoftargetingbiologicalprocesses
AT liuzinan atg8interactingmotifevolutionandfunctioninselectiveautophagyoftargetingbiologicalprocesses
AT mozulong atg8interactingmotifevolutionandfunctioninselectiveautophagyoftargetingbiologicalprocesses
AT guoshaoying atg8interactingmotifevolutionandfunctioninselectiveautophagyoftargetingbiologicalprocesses
AT liuyunfeng atg8interactingmotifevolutionandfunctioninselectiveautophagyoftargetingbiologicalprocesses
AT xieqingjun atg8interactingmotifevolutionandfunctioninselectiveautophagyoftargetingbiologicalprocesses