Cargando…
ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes
Autophagy is an evolutionarily conserved vacuolar process functioning in the degradation of cellular components for reuse. In plants, autophagy is generally activated upon stress and its regulation is executed by numbers of AuTophaGy-related genes (ATGs), of which the ATG8 plays a dual role in both...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666691/ https://www.ncbi.nlm.nih.gov/pubmed/34912364 http://dx.doi.org/10.3389/fpls.2021.783881 |
_version_ | 1784614265104105472 |
---|---|
author | Liu, Wanqing Liu, Zinan Mo, Zulong Guo, Shaoying Liu, Yunfeng Xie, Qingjun |
author_facet | Liu, Wanqing Liu, Zinan Mo, Zulong Guo, Shaoying Liu, Yunfeng Xie, Qingjun |
author_sort | Liu, Wanqing |
collection | PubMed |
description | Autophagy is an evolutionarily conserved vacuolar process functioning in the degradation of cellular components for reuse. In plants, autophagy is generally activated upon stress and its regulation is executed by numbers of AuTophaGy-related genes (ATGs), of which the ATG8 plays a dual role in both biogenesis of autophagosomes and recruitment of ATG8-interacting motif (AIM) anchored selective autophagy receptors (SARs). Such motif is either termed as AIM or ubiquitin-interacting motif (UIM), corresponding to the LC3-interacting region (LIR)/AIM docking site (LDS) or the UIM docking site (UDS) of ATG8, respectively. To date, dozens of AIM or UIM containing SARs have been characterized. However, the knowledge of these motifs is still obscured. In this review, we intend to summarize the current understanding of SAR proteins and discuss the conservation and diversification of the AIMs/UIMs, expectantly providing new insights into the evolution of them in various biological processes in plants. |
format | Online Article Text |
id | pubmed-8666691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86666912021-12-14 ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes Liu, Wanqing Liu, Zinan Mo, Zulong Guo, Shaoying Liu, Yunfeng Xie, Qingjun Front Plant Sci Plant Science Autophagy is an evolutionarily conserved vacuolar process functioning in the degradation of cellular components for reuse. In plants, autophagy is generally activated upon stress and its regulation is executed by numbers of AuTophaGy-related genes (ATGs), of which the ATG8 plays a dual role in both biogenesis of autophagosomes and recruitment of ATG8-interacting motif (AIM) anchored selective autophagy receptors (SARs). Such motif is either termed as AIM or ubiquitin-interacting motif (UIM), corresponding to the LC3-interacting region (LIR)/AIM docking site (LDS) or the UIM docking site (UDS) of ATG8, respectively. To date, dozens of AIM or UIM containing SARs have been characterized. However, the knowledge of these motifs is still obscured. In this review, we intend to summarize the current understanding of SAR proteins and discuss the conservation and diversification of the AIMs/UIMs, expectantly providing new insights into the evolution of them in various biological processes in plants. Frontiers Media S.A. 2021-11-29 /pmc/articles/PMC8666691/ /pubmed/34912364 http://dx.doi.org/10.3389/fpls.2021.783881 Text en Copyright © 2021 Liu, Liu, Mo, Guo, Liu and Xie. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Plant Science Liu, Wanqing Liu, Zinan Mo, Zulong Guo, Shaoying Liu, Yunfeng Xie, Qingjun ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes |
title | ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes |
title_full | ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes |
title_fullStr | ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes |
title_full_unstemmed | ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes |
title_short | ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes |
title_sort | atg8-interacting motif: evolution and function in selective autophagy of targeting biological processes |
topic | Plant Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666691/ https://www.ncbi.nlm.nih.gov/pubmed/34912364 http://dx.doi.org/10.3389/fpls.2021.783881 |
work_keys_str_mv | AT liuwanqing atg8interactingmotifevolutionandfunctioninselectiveautophagyoftargetingbiologicalprocesses AT liuzinan atg8interactingmotifevolutionandfunctioninselectiveautophagyoftargetingbiologicalprocesses AT mozulong atg8interactingmotifevolutionandfunctioninselectiveautophagyoftargetingbiologicalprocesses AT guoshaoying atg8interactingmotifevolutionandfunctioninselectiveautophagyoftargetingbiologicalprocesses AT liuyunfeng atg8interactingmotifevolutionandfunctioninselectiveautophagyoftargetingbiologicalprocesses AT xieqingjun atg8interactingmotifevolutionandfunctioninselectiveautophagyoftargetingbiologicalprocesses |