PI3K-driven HER2 expression is a potential therapeutic target in colorectal cancer stem cells

OBJECTIVE: Cancer stem cells are responsible for tumour spreading and relapse. Human epidermal growth factor receptor 2 (HER2) expression is a negative prognostic factor in colorectal cancer (CRC) and a potential target in tumours carrying the gene amplification. Our aim was to define the expression...

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Detalles Bibliográficos
Autores principales: Mangiapane, Laura Rosa, Nicotra, Annalisa, Turdo, Alice, Gaggianesi, Miriam, Bianca, Paola, Di Franco, Simone, Sardina, Davide Stefano, Veschi, Veronica, Signore, Michele, Beyes, Sven, Fagnocchi, Luca, Fiori, Micol Eleonora, Bongiorno, Maria Rita, Lo Iacono, Melania, Pillitteri, Irene, Ganduscio, Gloria, Gulotta, Gaspare, Medema, Jan Paul, Zippo, Alessio, Todaro, Matilde, De Maria, Ruggero, Stassi, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Colon
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666826/
https://www.ncbi.nlm.nih.gov/pubmed/33436496
http://dx.doi.org/10.1136/gutjnl-2020-323553

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