Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale

Delivery of exogenous mRNA using lipid nanoparticles (LNPs) is a promising strategy for therapeutics. However, a bottleneck remains in the poor understanding of the parameters that correlate with endosomal escape versus cytotoxicity. To address this problem, we compared the endosomal distribution of...

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Detalles Bibliográficos
Autores principales: Paramasivam, Prasath, Franke, Christian, Stöter, Martin, Höijer, Andreas, Bartesaghi, Stefano, Sabirsh, Alan, Lindfors, Lennart, Arteta, Marianna Yanez, Dahlén, Anders, Bak, Annette, Andersson, Shalini, Kalaidzidis, Yannis, Bickle, Marc, Zerial, Marino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666849/
https://www.ncbi.nlm.nih.gov/pubmed/34882187
http://dx.doi.org/10.1083/jcb.202110137

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