Cargando…

Susceptibility to preeclampsia is associated with a 50-bp insertion/deletion polymorphism at the promoter region of the SOD1 gene

OBJECTIVE: There is much evidence that oxidative stress is involved in the pathogenesis of preeclampsia (PE). A 50 bp insertion/deletion (Ins/Del) functional polymorphism in the promoter region of SOD1 has been reported. Due to a total lack of data, the aim of this study was to investigate the assoc...

Descripción completa

Detalles Bibliográficos
Autores principales: Namdari, Somayeh, Saadat, Mostafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666992/
https://www.ncbi.nlm.nih.gov/pubmed/34866367
http://dx.doi.org/10.4274/jtgga.galenos.2021.2021.0005
_version_ 1784614310041878528
author Namdari, Somayeh
Saadat, Mostafa
author_facet Namdari, Somayeh
Saadat, Mostafa
author_sort Namdari, Somayeh
collection PubMed
description OBJECTIVE: There is much evidence that oxidative stress is involved in the pathogenesis of preeclampsia (PE). A 50 bp insertion/deletion (Ins/Del) functional polymorphism in the promoter region of SOD1 has been reported. Due to a total lack of data, the aim of this study was to investigate the association between the SOD1 (Ins/Del) polymorphism and the risk of PE. MATERIAL AND METHODS: The current hospital-based case-control study included a total of 172 preeclamptic and 171 non-preeclamptic pregnancies. Genotyping was performed using the polymerase chain reaction method. RESULTS: Statistical analysis revealed that the Del/Del genotype significantly correlated with susceptibility to PE [odds ratio (OR): 6.53, 95% confidence interval (CI): 1.43-29.7, p=0.015]. Since maternal body mass index, family history of PE in first degree relatives, and educational levels were statistically associated with the susceptibility to PE, further analyses were carried out in order to estimate the adjusted ORs. After adjustment for aforementioned variables, the Del/Del genotype increased the risk of PE (OR: 5.98, 95% CI: 1.21-29.5, p=0.028). CONCLUSION: The 50 bp Ins/Del in promoter region of the SOD1 gene could be an intriguing susceptibility factor for developing preeclampsia in Iranian Caucasians.
format Online
Article
Text
id pubmed-8666992
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Galenos Publishing
record_format MEDLINE/PubMed
spelling pubmed-86669922021-12-16 Susceptibility to preeclampsia is associated with a 50-bp insertion/deletion polymorphism at the promoter region of the SOD1 gene Namdari, Somayeh Saadat, Mostafa J Turk Ger Gynecol Assoc Original Investigation OBJECTIVE: There is much evidence that oxidative stress is involved in the pathogenesis of preeclampsia (PE). A 50 bp insertion/deletion (Ins/Del) functional polymorphism in the promoter region of SOD1 has been reported. Due to a total lack of data, the aim of this study was to investigate the association between the SOD1 (Ins/Del) polymorphism and the risk of PE. MATERIAL AND METHODS: The current hospital-based case-control study included a total of 172 preeclamptic and 171 non-preeclamptic pregnancies. Genotyping was performed using the polymerase chain reaction method. RESULTS: Statistical analysis revealed that the Del/Del genotype significantly correlated with susceptibility to PE [odds ratio (OR): 6.53, 95% confidence interval (CI): 1.43-29.7, p=0.015]. Since maternal body mass index, family history of PE in first degree relatives, and educational levels were statistically associated with the susceptibility to PE, further analyses were carried out in order to estimate the adjusted ORs. After adjustment for aforementioned variables, the Del/Del genotype increased the risk of PE (OR: 5.98, 95% CI: 1.21-29.5, p=0.028). CONCLUSION: The 50 bp Ins/Del in promoter region of the SOD1 gene could be an intriguing susceptibility factor for developing preeclampsia in Iranian Caucasians. Galenos Publishing 2021-12 2021-12-06 /pmc/articles/PMC8666992/ /pubmed/34866367 http://dx.doi.org/10.4274/jtgga.galenos.2021.2021.0005 Text en © Copyright 2021 by the Turkish-German Gynecological Education and Research Foundation https://creativecommons.org/licenses/by-nc-nd/4.0/Journal of the Turkish-German Gynecological Association published by Galenos Publishing House.
spellingShingle Original Investigation
Namdari, Somayeh
Saadat, Mostafa
Susceptibility to preeclampsia is associated with a 50-bp insertion/deletion polymorphism at the promoter region of the SOD1 gene
title Susceptibility to preeclampsia is associated with a 50-bp insertion/deletion polymorphism at the promoter region of the SOD1 gene
title_full Susceptibility to preeclampsia is associated with a 50-bp insertion/deletion polymorphism at the promoter region of the SOD1 gene
title_fullStr Susceptibility to preeclampsia is associated with a 50-bp insertion/deletion polymorphism at the promoter region of the SOD1 gene
title_full_unstemmed Susceptibility to preeclampsia is associated with a 50-bp insertion/deletion polymorphism at the promoter region of the SOD1 gene
title_short Susceptibility to preeclampsia is associated with a 50-bp insertion/deletion polymorphism at the promoter region of the SOD1 gene
title_sort susceptibility to preeclampsia is associated with a 50-bp insertion/deletion polymorphism at the promoter region of the sod1 gene
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666992/
https://www.ncbi.nlm.nih.gov/pubmed/34866367
http://dx.doi.org/10.4274/jtgga.galenos.2021.2021.0005
work_keys_str_mv AT namdarisomayeh susceptibilitytopreeclampsiaisassociatedwitha50bpinsertiondeletionpolymorphismatthepromoterregionofthesod1gene
AT saadatmostafa susceptibilitytopreeclampsiaisassociatedwitha50bpinsertiondeletionpolymorphismatthepromoterregionofthesod1gene