Conditional Deletion of Pdcd1 Identifies the Cell-Intrinsic Action of PD-1 on Functional CD8 T Cell Subsets for Antitumor Efficacy

Programmed cell death-1 (PD-1) blockade has a profound effect on the ability of the immune system to eliminate tumors, but many questions remain about the cell types involved and the underlying mechanisms of immune activation. To shed some light on this, the cellular and molecular events following i...

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Detalles Bibliográficos
Autores principales: Raghavan, Sukanya, Tovbis-Shifrin, Nataliya, Kochel, Christina, Sawant, Anandi, Mello, Marielle, Sathe, Manjiri, Blumenschein, Wendy, Muise, Eric S., Chackerian, Alissa, Pinheiro, Elaine M., Rosahl, Thomas W., Luche, Hervé, de Waal Malefyt, Rene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667167/
https://www.ncbi.nlm.nih.gov/pubmed/34912335
http://dx.doi.org/10.3389/fimmu.2021.752348

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