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A minute primary gastric synovial sarcoma with ulcer: a case report
BACKGROUND: Synovial sarcomas are a rare type of high-grade sarcomas with unknown cell origin. They arise predominantly in the soft tissues but rarely in the stomach. We recently encountered a rare case of minute gastric synovial sarcoma. CASE PRESENTATION: A 61-year-old Japanese woman was pointed o...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667358/ https://www.ncbi.nlm.nih.gov/pubmed/34895269 http://dx.doi.org/10.1186/s13000-021-01175-3 |
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author | Yoshiyasu, Kanako Kono, Hiroshi Hojo, Yudai Ishida, Yoshinori Tamura, Akio Nakai, Keisuke Oshima, Tadayuki Miwa, Hiroto Shinohara, Hisashi Hirota, Seiichi |
author_facet | Yoshiyasu, Kanako Kono, Hiroshi Hojo, Yudai Ishida, Yoshinori Tamura, Akio Nakai, Keisuke Oshima, Tadayuki Miwa, Hiroto Shinohara, Hisashi Hirota, Seiichi |
author_sort | Yoshiyasu, Kanako |
collection | PubMed |
description | BACKGROUND: Synovial sarcomas are a rare type of high-grade sarcomas with unknown cell origin. They arise predominantly in the soft tissues but rarely in the stomach. We recently encountered a rare case of minute gastric synovial sarcoma. CASE PRESENTATION: A 61-year-old Japanese woman was pointed out edematous erosion at the body of the stomach. Biopsy specimen showed dense proliferation of spindle-shaped tumor cells mixed with smooth muscle fibers of the muscularis mucosae. Although the definite histological diagnosis was undetermined, the patient underwent laparoscopic wedge resection of the stomach. Histological examination of the resected sample revealed that the maximum diameter of the tumor was only 6 mm and that dense proliferation of rather uniform spindle tumor cells were observed mainly in the submucosa. Immunohistochemistry showed that they were positive for pan-keratin, CD99 and TLE1. SS18-SSX fusion-specific antibody gave diffuse positive staining to the tumor cells, and analysis using mRNA extracted from paraffin sections revealed that the tumor had SS18-SSX1 fusion gene. Thus, it was diagnosed as gastric synovial sarcoma, monophasic fibrous type. CONCLUSIONS: Primary synovial sarcoma of the stomach is rare and only 47 cases have been reported in the English literature to date. The maximum diameter of the lesion of our case was 6 mm which is the smallest among them. |
format | Online Article Text |
id | pubmed-8667358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-86673582021-12-13 A minute primary gastric synovial sarcoma with ulcer: a case report Yoshiyasu, Kanako Kono, Hiroshi Hojo, Yudai Ishida, Yoshinori Tamura, Akio Nakai, Keisuke Oshima, Tadayuki Miwa, Hiroto Shinohara, Hisashi Hirota, Seiichi Diagn Pathol Case Report BACKGROUND: Synovial sarcomas are a rare type of high-grade sarcomas with unknown cell origin. They arise predominantly in the soft tissues but rarely in the stomach. We recently encountered a rare case of minute gastric synovial sarcoma. CASE PRESENTATION: A 61-year-old Japanese woman was pointed out edematous erosion at the body of the stomach. Biopsy specimen showed dense proliferation of spindle-shaped tumor cells mixed with smooth muscle fibers of the muscularis mucosae. Although the definite histological diagnosis was undetermined, the patient underwent laparoscopic wedge resection of the stomach. Histological examination of the resected sample revealed that the maximum diameter of the tumor was only 6 mm and that dense proliferation of rather uniform spindle tumor cells were observed mainly in the submucosa. Immunohistochemistry showed that they were positive for pan-keratin, CD99 and TLE1. SS18-SSX fusion-specific antibody gave diffuse positive staining to the tumor cells, and analysis using mRNA extracted from paraffin sections revealed that the tumor had SS18-SSX1 fusion gene. Thus, it was diagnosed as gastric synovial sarcoma, monophasic fibrous type. CONCLUSIONS: Primary synovial sarcoma of the stomach is rare and only 47 cases have been reported in the English literature to date. The maximum diameter of the lesion of our case was 6 mm which is the smallest among them. BioMed Central 2021-12-13 /pmc/articles/PMC8667358/ /pubmed/34895269 http://dx.doi.org/10.1186/s13000-021-01175-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Yoshiyasu, Kanako Kono, Hiroshi Hojo, Yudai Ishida, Yoshinori Tamura, Akio Nakai, Keisuke Oshima, Tadayuki Miwa, Hiroto Shinohara, Hisashi Hirota, Seiichi A minute primary gastric synovial sarcoma with ulcer: a case report |
title | A minute primary gastric synovial sarcoma with ulcer: a case report |
title_full | A minute primary gastric synovial sarcoma with ulcer: a case report |
title_fullStr | A minute primary gastric synovial sarcoma with ulcer: a case report |
title_full_unstemmed | A minute primary gastric synovial sarcoma with ulcer: a case report |
title_short | A minute primary gastric synovial sarcoma with ulcer: a case report |
title_sort | minute primary gastric synovial sarcoma with ulcer: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667358/ https://www.ncbi.nlm.nih.gov/pubmed/34895269 http://dx.doi.org/10.1186/s13000-021-01175-3 |
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