Severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange: a case report

BACKGROUND: Leptospirosis is a common zoonotic infection caused by the spirochete Leptospira. The disease is more prevalent in the tropics, causing subclinical to severe illness leading to high morbidity and mortality. CASE PRESENTATION: A 77-year-old healthy Sri Lankan man presented to the Teaching...

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Detalles Bibliográficos
Autores principales: Kularathna, Manana Dewage Sankani Vishvara, Kularatne, Senanayake Abeysinghe Mudiyanselage, Pathirage, Manoji, Nanayakkara, Pala Thanthirige Madhushi Anuradha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667368/
https://www.ncbi.nlm.nih.gov/pubmed/34903283
http://dx.doi.org/10.1186/s13256-021-03135-3
Descripción
Sumario:BACKGROUND: Leptospirosis is a common zoonotic infection caused by the spirochete Leptospira. The disease is more prevalent in the tropics, causing subclinical to severe illness leading to high morbidity and mortality. CASE PRESENTATION: A 77-year-old healthy Sri Lankan man presented to the Teaching Hospital Peradeniya with severe leptospirosis complicated with acute kidney injury, pulmonary hemorrhages, myocarditis, and severe thrombocytopenia. He was deteriorating despite treatment with intravenous antibiotics and methylprednisolone boluses. He made a dramatic improvement with two cycles of plasma exchange. CONCLUSION: Therapeutic plasma exchange is a life-saving treatment modality in severe leptospirosis with multiorgan failure.

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