Severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange: a case report

BACKGROUND: Leptospirosis is a common zoonotic infection caused by the spirochete Leptospira. The disease is more prevalent in the tropics, causing subclinical to severe illness leading to high morbidity and mortality. CASE PRESENTATION: A 77-year-old healthy Sri Lankan man presented to the Teaching...

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Autores principales: Kularathna, Manana Dewage Sankani Vishvara, Kularatne, Senanayake Abeysinghe Mudiyanselage, Pathirage, Manoji, Nanayakkara, Pala Thanthirige Madhushi Anuradha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667368/
https://www.ncbi.nlm.nih.gov/pubmed/34903283
http://dx.doi.org/10.1186/s13256-021-03135-3
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author Kularathna, Manana Dewage Sankani Vishvara
Kularatne, Senanayake Abeysinghe Mudiyanselage
Pathirage, Manoji
Nanayakkara, Pala Thanthirige Madhushi Anuradha
author_facet Kularathna, Manana Dewage Sankani Vishvara
Kularatne, Senanayake Abeysinghe Mudiyanselage
Pathirage, Manoji
Nanayakkara, Pala Thanthirige Madhushi Anuradha
author_sort Kularathna, Manana Dewage Sankani Vishvara
collection PubMed
description BACKGROUND: Leptospirosis is a common zoonotic infection caused by the spirochete Leptospira. The disease is more prevalent in the tropics, causing subclinical to severe illness leading to high morbidity and mortality. CASE PRESENTATION: A 77-year-old healthy Sri Lankan man presented to the Teaching Hospital Peradeniya with severe leptospirosis complicated with acute kidney injury, pulmonary hemorrhages, myocarditis, and severe thrombocytopenia. He was deteriorating despite treatment with intravenous antibiotics and methylprednisolone boluses. He made a dramatic improvement with two cycles of plasma exchange. CONCLUSION: Therapeutic plasma exchange is a life-saving treatment modality in severe leptospirosis with multiorgan failure.
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spelling pubmed-86673682021-12-13 Severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange: a case report Kularathna, Manana Dewage Sankani Vishvara Kularatne, Senanayake Abeysinghe Mudiyanselage Pathirage, Manoji Nanayakkara, Pala Thanthirige Madhushi Anuradha J Med Case Rep Case Report BACKGROUND: Leptospirosis is a common zoonotic infection caused by the spirochete Leptospira. The disease is more prevalent in the tropics, causing subclinical to severe illness leading to high morbidity and mortality. CASE PRESENTATION: A 77-year-old healthy Sri Lankan man presented to the Teaching Hospital Peradeniya with severe leptospirosis complicated with acute kidney injury, pulmonary hemorrhages, myocarditis, and severe thrombocytopenia. He was deteriorating despite treatment with intravenous antibiotics and methylprednisolone boluses. He made a dramatic improvement with two cycles of plasma exchange. CONCLUSION: Therapeutic plasma exchange is a life-saving treatment modality in severe leptospirosis with multiorgan failure. BioMed Central 2021-12-13 /pmc/articles/PMC8667368/ /pubmed/34903283 http://dx.doi.org/10.1186/s13256-021-03135-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Kularathna, Manana Dewage Sankani Vishvara
Kularatne, Senanayake Abeysinghe Mudiyanselage
Pathirage, Manoji
Nanayakkara, Pala Thanthirige Madhushi Anuradha
Severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange: a case report
title Severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange: a case report
title_full Severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange: a case report
title_fullStr Severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange: a case report
title_full_unstemmed Severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange: a case report
title_short Severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange: a case report
title_sort severe leptospirosis complicated with multiorgan dysfunction successfully managed with plasma exchange: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667368/
https://www.ncbi.nlm.nih.gov/pubmed/34903283
http://dx.doi.org/10.1186/s13256-021-03135-3
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