Cargando…

Review: The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish

The neural crest (NC) is a multipotent cell population in vertebrate embryos with extraordinary migratory capacity. The NC is crucial for vertebrate development and forms a myriad of cell derivatives throughout the body, including pigment cells, neuronal cells of the peripheral nervous system, cardi...

Descripción completa

Detalles Bibliográficos
Autores principales: Sutton, Gemma, Kelsh, Robert N., Scholpp, Steffen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667473/
https://www.ncbi.nlm.nih.gov/pubmed/34912811
http://dx.doi.org/10.3389/fcell.2021.782445
_version_ 1784614394075807744
author Sutton, Gemma
Kelsh, Robert N.
Scholpp, Steffen
author_facet Sutton, Gemma
Kelsh, Robert N.
Scholpp, Steffen
author_sort Sutton, Gemma
collection PubMed
description The neural crest (NC) is a multipotent cell population in vertebrate embryos with extraordinary migratory capacity. The NC is crucial for vertebrate development and forms a myriad of cell derivatives throughout the body, including pigment cells, neuronal cells of the peripheral nervous system, cardiomyocytes and skeletogenic cells in craniofacial tissue. NC induction occurs at the end of gastrulation when the multipotent population of NC progenitors emerges in the ectodermal germ layer in the neural plate border region. In the process of NC fate specification, fate-specific markers are expressed in multipotent progenitors, which subsequently adopt a specific fate. Thus, NC cells delaminate from the neural plate border and migrate extensively throughout the embryo until they differentiate into various cell derivatives. Multiple signalling pathways regulate the processes of NC induction and specification. This review explores the ongoing role of the Wnt/β-catenin signalling pathway during NC development, focusing on research undertaken in the Teleost model organism, zebrafish (Danio rerio). We discuss the function of the Wnt/β-catenin signalling pathway in inducing the NC within the neural plate border and the specification of melanocytes from the NC. The current understanding of NC development suggests a continual role of Wnt/β-catenin signalling in activating and maintaining the gene regulatory network during NC induction and pigment cell specification. We relate this to emerging models and hypotheses on NC fate restriction. Finally, we highlight the ongoing challenges facing NC research, current gaps in knowledge, and this field’s potential future directions.
format Online
Article
Text
id pubmed-8667473
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-86674732021-12-14 Review: The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish Sutton, Gemma Kelsh, Robert N. Scholpp, Steffen Front Cell Dev Biol Cell and Developmental Biology The neural crest (NC) is a multipotent cell population in vertebrate embryos with extraordinary migratory capacity. The NC is crucial for vertebrate development and forms a myriad of cell derivatives throughout the body, including pigment cells, neuronal cells of the peripheral nervous system, cardiomyocytes and skeletogenic cells in craniofacial tissue. NC induction occurs at the end of gastrulation when the multipotent population of NC progenitors emerges in the ectodermal germ layer in the neural plate border region. In the process of NC fate specification, fate-specific markers are expressed in multipotent progenitors, which subsequently adopt a specific fate. Thus, NC cells delaminate from the neural plate border and migrate extensively throughout the embryo until they differentiate into various cell derivatives. Multiple signalling pathways regulate the processes of NC induction and specification. This review explores the ongoing role of the Wnt/β-catenin signalling pathway during NC development, focusing on research undertaken in the Teleost model organism, zebrafish (Danio rerio). We discuss the function of the Wnt/β-catenin signalling pathway in inducing the NC within the neural plate border and the specification of melanocytes from the NC. The current understanding of NC development suggests a continual role of Wnt/β-catenin signalling in activating and maintaining the gene regulatory network during NC induction and pigment cell specification. We relate this to emerging models and hypotheses on NC fate restriction. Finally, we highlight the ongoing challenges facing NC research, current gaps in knowledge, and this field’s potential future directions. Frontiers Media S.A. 2021-11-29 /pmc/articles/PMC8667473/ /pubmed/34912811 http://dx.doi.org/10.3389/fcell.2021.782445 Text en Copyright © 2021 Sutton, Kelsh and Scholpp. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Sutton, Gemma
Kelsh, Robert N.
Scholpp, Steffen
Review: The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish
title Review: The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish
title_full Review: The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish
title_fullStr Review: The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish
title_full_unstemmed Review: The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish
title_short Review: The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish
title_sort review: the role of wnt/β-catenin signalling in neural crest development in zebrafish
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667473/
https://www.ncbi.nlm.nih.gov/pubmed/34912811
http://dx.doi.org/10.3389/fcell.2021.782445
work_keys_str_mv AT suttongemma reviewtheroleofwntbcateninsignallinginneuralcrestdevelopmentinzebrafish
AT kelshrobertn reviewtheroleofwntbcateninsignallinginneuralcrestdevelopmentinzebrafish
AT scholppsteffen reviewtheroleofwntbcateninsignallinginneuralcrestdevelopmentinzebrafish